Graduate Program in Immunology & Microbial Pathogenesis
Faculty
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David Abraham, PhD Professor, Microbiology & Immunology Parasite immunology; role of eosinophils, neutrophils, and macrophages in innate and adaptive immunity to helminth parasite infections; development of vaccines against nematode infections; genetic control of protective immunity to parasites; chemotherapy of leishmaniasis; diagnosis of strongyloidiasis. |
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Kishore Alugupalli, PhD Assistant Professor, Microbiology & Immunology Molecular basis of bacterial pathogenesis using murine infection models; B 1 b lymphocytes in T cell–independent IgM memory; role of Toll-like receptors in innate and adaptive immune responses. |
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Catherine Calkins, PhD Professor, Microbiology & Immunology Cellular immunology; immunoregulation of antiself reactivity; autoimmune disease; autoimmune hemolytic anemia; antiviral immunity; immunopathogenesis of hepatitis B virus. |
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Kerry S. Campbell, PhD Adjunct Research Associate Professor, Microbiology & Immunology Fox Chase Cancer Center Molecular mechanisms by which killer cell immunoglobulin-like receptors (KIR)regulate human natural killer (NK) cell responses; signal transduction in natural killer cells. |
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Laurence C. Eisenlohr, VMD, PhD Professor, Microbiology & Immunology Cell biology of MHC class I– and class II–restricted antigen processing of viral antigens; T-cell responses and memory to viral antigens; vaccinology; antitumor immunity. |
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Phyllis Flomenberg, MD Associate Professor, Medicine Adenoviruses; Vaccinia virus; viral immunology; tumor immunology; immunotherapy. |
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Richard Hardy, PhD Adjunct Research Professor, Microbiology & Immunology Fox Chase Cancer Center Developmental immunology of B cells, including their generation from stem cells in fetal liver and bone marrow; regulation of B-cell development by pre-BCR and BCR signaling; development of B-cell subsets, including B-1 B cells, with relevance to autoimmunity and leukemia. Most of this work uses the mouse as a model system, but recent studies include analysis of B cell receptors in chronic lymphocytic leukemia patient cells and a genetic screen in the zebrafish. |
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D. Craig Hooper, PhD Associate Professor, Cancer Biology Neuroimmunology; virus clearance from the central nervous system (CNS); CNS tumor immunity; regulation of blood-brain barrier function; immune effector delivery into the CNS; CD4 T-cell priming; inflammation; autoimmunity; immunopathogenesis; contribution of free radicals to immunity; CNS vaccine development. |
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Tim Manser, PhD Professor and Chairperson, Microbiology & Immunology Role of antigen receptor specificity in B-cell selection, tolerance, and memory; germinal center reaction; regulation of B-cell responses by inhibitory Fc receptors. |
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James P. McGettigan, PhD Assistant Professor, Microbiology & Immunology Investigating vaccine-induced T and B cell responses against viral infections. |
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Steven McKenzie, MD, PhD Professor, Medicine Murine models of immune-mediated thrombocytopenia and thrombosis syndromes; molecular genetics of Fc receptor evolution and function; genetically modified mouse models of autoimmune disease and host defense. |
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Fabienne M. Paumet, PhD Assistant Professor, Microbiology & Immunology Role of phagocytosis in the pathogenesis of infectious diseases; Role of phagocytosis in mast cell function in allergy |
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Richard G. Pestell, MD, PhD Professor & Chairperson, Cancer Biology Molecular mechanisms and gene therapy of breast and prostate cancer; cancer stem cells. |
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Glenn Rall, PhD Adjunct Research Associate Professor, Microbiology & Immunology Fox Chase Cancer Center Viral spread within neurons; recruitment and function of the immune response to neurotropic viral challenges; transgenic models of viral pathogenesis. |
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Ulrich Rodeck, MD, PhD Professor, Dermatology & Cutaneous Biology Regulation of epithelial cell fate by the epidermal growth factor receptor and associated signal transduction events; molecular mechanisms leading to adverse events of cancer therapy; adverse event reduction by developing drugs targeted to disease sites; zebrafish as an in vivo model system to investigate whole organism genotoxic stress responses. |
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Michael J. Root, MD, PhD Associate Professor, Biochemistry & Molecular Biology Mechanisms of viral and cell-cell membrane fusion; HIV entry inhibitor design and vaccine development; Osteoclast formation/macrophage fusion |
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Abdolmohamad Rostami, MD, PhD Professor & Chairperson, Neurology Neuroimmunology, etiology and pathogenesis of multiple sclerosis (MS) role of Th1 and Th17 cells in the pathogenesis of Experimental Autoimmune Encephalomyelitis (EAE) and MS; role of IL-27 and GM-CSF in EAE and MS pathogenesis; mechanisms of tolerance induction in autoimmune inflammation of CNS. |
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Takami Sato, MD, PhD Professor, Medical Oncology Cancer immunotherapies; immunoembolization of hepatic metastasis from uveal melanoma with GM-CSF, adaptive immunotherapy with natural killer cell, IL-10 immunoadhesin. |
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Matthias J. Schnell, PhD Professor, Microbiology & Immunology Development of novel vaccines and viral pathogenesis; recombinant rhabdoviruses as vaccine vectors for HIV-1 and other infectious diseases; interaction of rhabdoviruses with the immune system; molecular pathogenesis of rabies virus. |
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Luis Sigal, DVM, PhD Adjunct Associate Professor, Microbiology & Immunology Fox Chase Cancer Center Antigen presentation in viral infections and mechanisms of natural and acquired resistance to ectromelia virus. |
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Linda D. Siracusa, PhD Professor, Microbiology & Immunology Immunogenetics: identification and characterization of genes, allelic variants, and mutations involved in mammalian disease processes. |
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Christopher Snyder, PhD Assistant Professor, Microbiology & Immunology Viral immunology; maintenance of adaptive immunity during chronic infections; T cell responses elicited by cytomegalovirus infection; activation of T cell effector functions by innate signals. |
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Yuri K. Sykulev, MD, PhD Professor, Microbiology & Immunology Molecular mechanisms regulating cytotoxic T lymphocyte activity. |
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Theodore F. Taraschi, PhD Professor, Pathology, Anatomy & Cell Biology Role of defective DNA mismatch repair in the development of antimalarial drug resistance |
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Scott A. Waldman, MD, PhD Professor & Chairperson, Pharmacology & Experimental Therapeutics Tumor suppressors and their signaling pathways in GI malignancies; Targeted diagnostics and therapeutics in cancer. |
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David Wiest, PhD Adjunct Associate Professor, Microbiology & Immunology Fox Chase Cancer Center Understanding the molecular basis for control of T lineage development by molecular effectors differentially elicited by distinct TCR isotypes. |
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Jianke Zhang, PhD Associate Professor, Microbiology & Immunology Immune tolerance and homeostasis; lymphocyte apoptosis; cytokine-receptor signal transduction; lymphocyte development; signal transduction mechanisms by the Fas/TNF receptor family members that mediate apoptosis and growth/proliferation; Toll-like receptor signaling; transgenic and gene targeting (knockout) analyses of protein functions in mice. |
