Hideko Kaji, PhD

Contact Dr. Kaji

1020 Locust Street
Room 456A JAH
Philadelphia, PA 19107

(215) 503-6547
(215) 923-7343 fax

Research and Clinical Interests
Translation (protein synthesis) from aminoacyl tRNA consists of four consecutive steps; initiation, elongation, termination, and recycling of the machinery of the protein synthesis for the next round of translation.

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Publications

Most recent Peer-reviewed Publications

1. Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors
2. Global cellular regulation including cardiac function by post-translational protein arginylation
3. Protein synthesis factors (RF1, RF2, RF3, RRF, and tmRNA) and peptidyl-tRNA hydrolase rescue stalled ribosomes at sense codons
4. Structural insights into initial and intermediate steps of the ribosome-recycling process
5. Protein modification by arginylation
6. Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP
7. The role of GTP in transient splitting of 70S ribosomes by RRF (ribosome recycling factor) and EF-G (elongation factor G)
8. Structural Insights into Ribosome Recycling Factor Interactions with the 70S Ribosome
9. Erratum: Novel activity of eukaryotic translocase, eEF2: Dissociation of the 80S ribosome into subunits with ATP but not with GTP (Nucleic Acids Research (2007) vol. 35 (4597-4607))
10. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling
11. Progression of the Ribosome Recycling Factor through the Ribosome Dissociates the Two Ribosomal Subunits
12. Novel activity of eukaryotic translocase, eEF2: Dissociation of the 80S ribosome into subunits with ATP but not with GTP
13. Ribosome recycling: An essential process of protein synthesis
14. Inhibition of antiassociation activity of translation initiation factor 3 by paromomycin
15. The ribosome-recycling step: Consensus or controversy?
16. The role of ribosome recycling factor in dissociation of 70S ribosomes into subunits
17. Interaction of RRF and EF-G from E. coli and T. thermophilus with ribosomes from both origins - Insight into the mechanism of the ribosome recycling step
18. Inhibition of human T-cell leukemia virus type I by the short oligoguanylic acids in vitro
19. In vivo effect of inactivation of ribosome recycling factor - Fate of ribosomes after unscheduled translation downstream of open reading frame
20. The history of deciphering the genetic code: Setting the record straight

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