Caleb B. Kallen, MD, PhD

Contact Dr. Kallen

1025 Locust Street
381 JAH
Philadelphia, PA 19107

(215) 503-6409
(215) 955-5577 fax

Research and Clinical Interests
Our lab is investigating the role of mRNA-binding proteins in obesity-related inflammatory processes with a focus on insulin sensitivity and atherosclerosis.

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Publications

Most recent Peer-reviewed Publications

1. Estrogen targets fat mass and glucose metabolism by acting in the brain
2. The mRNA-binding protein Zfp36 Is upregulated by β-adrenergic stimulation and represses IL-6 production in 3T3-L1 adipocytes
3. β-Catenin independent cross-control between the estradiol and Wnt pathways in osteoblasts
4. Intercalation of XR5944 with the estrogen response element is modulated by the tri-nucleotide spacer sequence between half-sites
5. The mRNA-binding protein HuR is regulated in the menstrual cycle and repressed in ectopic endometrium
6. The tri-nucleotide spacer sequence between estrogen response element half-sites is conserved and modulates ERα-mediated transcriptional responses
7. Location analysis for the estrogen receptor-α reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements
8. Clinical assessment of fracture risk and novel therapeutic strategies to combat osteoporosis
9. Reply of the Authors: An estrogen treatment may reverse a premature ovarian failure
10. Ovarian hyperstimulation after a short course of an oral contraceptive in a patient with premature ovarian failure
11. Two estrogen response element sequences near the PCNA gene are not responsible for its estrogen-enhanced expression in MCF7 cells
12. Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression
13. Steroid hormone synthesis in pregnancy
14. Immune testing in fertility practi Truth or deception?
15. The steroidogenic acute regulatory protein (StaR): A window into the complexities of intracellular cholesterol trafficking
16. Induction of matrix metalloproteinases and collagenolysis in chick embryonic membranes before hatching
17. Steroidogenic acute regulatory protein (StAR) acts on the outside of mitochondria to stimulate steroidogenesis
18. Unveiling the mechanism of action and regulation of the steroidogenic acute regulatory protein
19. Steroidogenic acute regulatory protein (StAR) is a sterol transfer protein
20. The mechanism of action of steroidogenic acute regulatory protein (StAR): StAR acts on the outside of mitochondria to stimulate steroidogenesis

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