Kishore Alugupalli, PhD

Contact Dr. Alugupalli

233 South 10th Street
Room 726 BLSB
Philadelphia, PA 19107

(215) 503-4554
(215) 503-4153 fax

Research and Clinical Interests
Immunology. B cell Memory - B1b Lymphocyte biology; Innate Immunity - Toll-like receptors and NOD-like receptors

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Publications

Most recent Peer-reviewed Publications

1. Deciphering the role of Toll-like receptors in humoral responses to Borreliae
2. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever
3. B1b lymphocyte-derived antibodies control Borrelia hermsii independent of Fcα/μ receptor and in the absence of host cell contact
4. Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection
5. T-cell-independent immune responses do not require Cxc ligand 13-mediated B1 cell migration
6. IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae
7. Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes
8. Genetic control of the innate immune response to Borrelia hermsii influences the course of relapsing fever in inbred strains of mice
9. Effective preexposure and postexposure prophylaxis of rabies with a highly attenuated recombinant rabies virus
10. B Cell Multitasking Is Required to Control Nematode Infection
11. A distinct role for B1b lymphocytes in T cell-independent immunity
12. Role of the innate immune system in autoimmune inflammatory demyelination
13. Complement factor H-binding protein, a putative virulence determinant of borrelia hermsii, is an antigenic target for protective B1b lymphocytes
14. The ArcA regulon and oxidative stress resistance in Haemophilus influenzae
15. MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses
16. Divide and conquer: Division of labor by B-1 B cells
17. B1b lymphocytes confer T cell-independent long-lasting immunity
18. Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis
19. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes
20. Serial determinations of platelet counts in mice by flow cytometry

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