Sophie Astrof, PhD

Contact Dr. Aplin

1025 Walnut Street
Suite 312
Philadelphia, PA 19107

(215) 955-9992
(215) 503-5731 fax

Research and Clinical Interests
The main focus of my lab is to understand cellular and molecular mechanisms of cardiovascular development in vertebrates. 

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Publications

Most recent Peer-reviewed Publications

1. Essential roles of fibronectin in the development of the left-right embryonic body plan
2. Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest
3. Fibronectins in vascular morphogenesis
4. A system for Cre-regulated RNA interference in vivo
5. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin
6. Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four
7. Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles
8. Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis