Dr. Fernandes-Alnemri Teresa Fernandes-Alnemri, PhD

Contact Dr. Fernandes-Alnemri

233 South 10th Street
Room 904a
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Research and Clinical Interests
The research in my lab focuses on the signaling pathways involved in caspase-1 activation and pro-inflammatory cytokine production by members of the NLR family including NLRP1, NLRP3, NLRC4, NOD1 & NOD2, and the interferon-induced protein AIM2 (absent in melanoma 2).

Show Details

Publications

Most recent Peer-reviewed Publications

  1. Restoration of ASC expression sensitizes colorectal cancer cells to genotoxic stress-induced caspase-independent cell death
  2. Ribotoxic stress through p38 mitogen-activated protein kinase activates in Vitro the human pyrin inflammasome
  3. A novel role for the mitochondrial HTRA2/OMI protease in aging
  4. Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging
  5. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation
  6. Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection
  7. Cutting edge: Mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence
  8. Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes
  9. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
  10. Functional consequences of a germline mutation in the leucine-rich repeat domain of NLRP3 Identified in an atypical autoinflammatory disorder
  11. Anti-inflammatory compounds parthenolide and bay 11-7082 are direct inhibitors of the inflammasome
  12. Cutting edge: NF-κB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
  13. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
  14. Chapter Thirteen Assembly, Purification, and Assay of the Activity of the ASC Pyroptosome
  15. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
  16. Mutations in NALP12 cause hereditary periodic fever syndromes
  17. Pyrin Activates the ASC Pyroptosome in Response to Engagement by Autoinflammatory PSTPIP1 Mutants
  18. The pyroptosome: A supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation
  19. Cryopyrin and pyrin activate caspase-1, but not NF-κB, via ASC oligomerization
  20. The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity

View All Publications