Mark Fortini, PhD

Contact Dr. Fortini

233 South 10th Street
Suite 830
Philadelphia, PA 19107

(215) 503-7322
fax

Research and Clinical Interests
Developmental signaling pathways involved in normal cellular patterning and cancer; proteolytic mechanisms in neurogenesis and neurodegeneration; trafficking and post-translational regulation of cell-surface receptors and ligands.

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Publications

Most recent Peer-reviewed Publications

1. Introduction-Notch in development and disease
2. Therapeutic approaches to modulating Notch signaling: Current challenges and future prospects
3. Deficient Notch signaling associated with neurogenic pecanex is compensated for by the unfolded protein response in Drosophila
4. Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function
5. In Vivo reconstitution of γ-secretase in Drosophila results in substrate specificity
6. Erratum to Retraction Notice to: The Big Brain Aquaporin Is Required for Endosome Maturation and Notch Receptor Trafficking [Cell, 133, (2008), 852-863]
7. Pharmacological analysis of Drosophila melanogaster γ-secretase with respect to differential proteolysis of notch and APP
8. Endocytic regulation of Notch signaling
9. Generation and characterization of monoclonal antibodies specific to Drosophila presenilin
10. Notch Signaling: The Core Pathway and Its Posttranslational Regulation
11. The Big Brain Aquaporin Is Required for Endosome Maturation and Notch Receptor Trafficking
12. Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
13. A role for presenilin in post-stress regulation: Effects of presenilin mutations on Ca2+ currents in Drosophila
14. Anticipating trouble from gene transcription
15. Drosophila as a model for human diseases: IRB and ICREA, Barcelona, Spain, October 5-7, 2006.
16. Modeling Clinically Heterogeneous Presenilin Mutations with Transgenic Drosophila
17. γ-Cleavage-Independent Functions of Presenilin, Nicastrin, and Aph-1 Regulate Cell-Junction Organization and Prevent Tau Toxicity In Vivo
18. Notch signaling: A different sort makes the cut
19. Functional reconstitution of γ-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2
20. PAR-1 for the course of neurodegeneration

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