Philippe Frank, PhD

Contact Dr. Frank

233 South 10th Street
Room 933
Philadelphia, PA 19107

(215) 503-9292
(215) 923-1098 fax

Research and Clinical Interests
Plasma lipoproteins, lipid transport, and atherosclerosis

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Publications

Most recent Peer-reviewed Publications

1. Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases
2. Cholesterol and breast cancer development
3. Atherosclerosis, caveolae and caveolin-1
4. Preface
5. Alterations in membrane caveolae and BK Ca channel activity in skin fibroblasts in Smith-Lemli-Opitz syndrome
6. Caveolin-2-deficient mice show increased sensitivity to endotoxemia
7. Role of cholesterol in the development and progression of breast cancer
8. A western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer
9. Celecoxib combined with atorvastatin prevents progression of atherosclerosis
10. Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D
11. The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
12. Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
13. Endothelial caveolae and caveolin-1 as key regulators of atherosclerosis
14. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": A transcriptional informatics analysis with validation
15. The reverse Warburg effect: Glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts
16. Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"
17. Endothelial cells isolated from caveolin-2 knockout mice display higher proliferation rate and cell cycle progression relative to their wild-type counterparts
18. The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
19. Clinical and translational implications of the caveolin gene family: Lessons from mouse models and human genetic disorders
20. Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy

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