Linda E. Greenbaum, MD

Contact Dr. Greenbaum

132 South 10th Street
Main Building, Suite 480
Philadelphia, PA 19107

(215) 955-8900
(215) 503-2527 fax

Research and Clinical Interests
Regulation of liver regeneration: role of transcription factors for cell cycle regulation, regulation of hepatocyte proliferation by microRNAs.

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Publications

Most recent Peer-reviewed Publications

1. Robust cellular reprogramming occurs spontaneously during liver regeneration
2. The role of paracrine signals during liver regeneration
3. The ductal plate: A source of progenitors and hepatocytes in the adult liver
4. Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential
5. The role of stem cells in liver repair and fibrosis
6. Tissue-specific regulation of mouse MicroRNA genes in endoderm-derived tissues
7. Nuclear factor κB up-regulation of CCAAT/enhancer-binding protein β mediates hepatocyte resistance to tumor necrosis factor α toxicity
8. From skin cells to hepatocytes: Advances in application of iPS cell technology
9. Foxl1 promotes liver repair following cholestatic injury in mice
10. Foxl1 is a marker of bipotential hepatic progenitor cells in mice
11. Hedgehog signaling in biliary fibrosis
12. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo
13. CCAAT/enhancer binding protein-β is a transcriptional regulator of peroxisome-proliferator-activated receptor-γ coactivator-1α in the regenerating liver
14. C/EBPβ activates E2F-regulated genes in vivo via recruitment of the coactivator CREB-binding protein/p300
15. Foxa2 integrates the transcriptional response of the hepatocyte to fasting
16. Identification of transcriptional networks during liver regeneration
17. Cell cycle regulation and hepatocarcinogenesis
18. Orthogonal analysis of C/EBPβ targets in vivo during liver proliferation
19. The proinflammatory mediators C3a and C5a are essential for liver regeneration
20. Activation of interleukin-6/STAT3 and liver regeneration following transplantation

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