Richard R. Hardy, PhD

Contact Dr. Hardy

333 Cottman Avenue
Fox Chase Cancer Center
Philadelphia, PA 19111

(215) 728-2469
(215) 728-2412 fax

Research and Clinical Interests
The developmental immunology of B lymphocytes, including their generation from stem cells in fetal liver and bone marrow;

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Publications

Most recent Peer-reviewed Publications

1. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
2. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
3. Positive and negative selection of natural autoreactive B cells
4. Positive and negative selection of natural autoreactive B cells.
5. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. 1991.
6. Molecular definition of the identity and activation of natural killer cells
7. Deciphering the transcriptional network of the dendritic cell lineage
8. Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors
9. Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks
10. Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
11. Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling
12. NEDD9 promotes oncogenic signaling in mammary tumor development
13. Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma
14. Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development
15. A role for cFLIP in B cell proliferation and stress MAPK regulation
16. Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3′ regulatory region of the immunoglobulin heavy chain locus
17. The immunological genome project: Networks of gene expression in immune cells
18. B cell receptor basal signaling regulates antigen-induced ig light chain rearrangements
19. Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors
20. Methodological approach to study the genomic profile of the human breast

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