Dr. Hoek Jan B Hoek, PhD

Contact Dr. Hoek

1020 Locust Street
Suite 269
Philadelphia, PA 19107

(215) 503-5016
(215) 923-2218 fax

Research and Clinical Interests
Systems biology of intracellular signal transduction networks; deregulation of cytokine and growth factor signaling in the liver associated with chronic alcohol consumption; early signaling responses during liver regeneration; bioenergetics and mitochondrial metabolism and its role in intracellular signaling and apoptosis.

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Publications

Most recent Peer-reviewed Publications

  1. Chronic Ethanol Feeding Alters miRNA Expression Dynamics During Liver Regeneration
  2. Coordinated Dynamic Gene Expression Changes in the Central Nucleus of the Amygdala During Alcohol Withdrawal
  3. Rapid Temporal Changes in the Expression of a Set of Neuromodulatory Genes During Alcohol Withdrawal in the Dorsal Vagal Complex: Molecular Evidence of Homeostatic Disturbance
  4. Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats
  5. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise
  6. Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats
  7. Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei
  8. Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
  9. Acetate causes alcohol hangover headache in rats
  10. PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells
  11. Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress
  12. Advancing alcohol biomarkers research
  13. Systems-level interactions between insulin-EGF networks amplify mitogenic signaling
  14. Temporal and functional profile of the transcriptional regulatory network in the early regenerative response to partial hepatectomy in the rat
  15. Adenine nucleotide changes in the remnant liver: An early signal for regeneration after partial hepatectomy
  16. Regulation of hexokinase binding to VDAC
  17. Experimental investigation and probabilistic modeling of switch-like signal transduction systems
  18. Ligand-dependent responses of the ErbB signaling network: Experimental and modeling analyses
  19. Multistrip Western blotting to increase quantitative data output
  20. TGF-β1 calcium signaling in osteoblasts

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