Dr. Jaynes James B. Jaynes, PhD

Contact Dr. Jaynes

1020 Locust Street
Room JAH-490
Philadelphia, PA 19107

(215) 503-4778
fax

Research and Clinical Interests
Embryos regulate their growth and development in many ways, but control of gene transcription is particularly important for directing cells along particular developmental pathways.

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Publications

Most recent Peer-reviewed Publications

  1. Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired
  2. Regulation of a duplicated locus: Drosophila sloppy paired is replete with functionally overlapping enhancers
  3. Ecdysone- and NO-Mediated Gene Regulation by Competing EcR/Usp and E75A Nuclear Receptors during Drosophila Development
  4. A chromatin insulator mediates transgene homing and very long-range enhancer-promoter communication
  5. The DNA-binding Polycomb-group protein Pleiohomeotic maintains both active and repressed transcriptional states through a single site
  6. The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
  7. Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference
  8. Embryonic even skipped-dependent muscle and heart cell fates are required for normal adult activity, heart function, and lifespan
  9. Erratum: Drawing lines in the sand: Even skipped et al. and parasegment boundaries (Developmental Biology (2004) 269 (609-622) DOI: 10.1016/j.ydbio. 2004.03.001)
  10. Drawing lines in the sand: Even skipped et al. and parasegment boundaries
  11. Embryonic origins of a motor system: Motor dendrites form a myotopic map in Drosophila
  12. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
  13. Specification of Motoneuron Fate in Drosophila: Integration of Positive and Negative Transcription Factor Inputs by a Minimal eve Enhancer
  14. Even-skipped, acting as a repressor, regulates axonal projections in Drosophila
  15. Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila
  16. Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm
  17. The repressor activity of Even-skipped is highly conserved, and is sufficient to activate engrailed and to regulate both the spacing and stability of parasegment boundaries
  18. A complex array of DNA-binding proteins required for pairing-sensitive silencing by a polycomb group response element from the Drosophila engrailed gene
  19. Sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein
  20. Drosophila SAP18, a member of the Sin3/Rpd3 histone deacetylase complex, interacts with Bicoid and inhibits its activity

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