Erica S. Johnson, PhD

Contact Dr. Johnson

233 South 10th Street
Room 231
Philadelphia, PA 19107

(215) 503-4616
(215) 503-5393 fax

Research and Clinical Interests
Covalent modifications of proteins play critical roles in most cellular processes through their ability to cause rapid and reversible changes in the functions of pre-existing proteins, multi-protein complexes and subcellular structures.

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Publications

Most recent Peer-reviewed Publications

1. Global analysis of SUMO chain function reveals multiple roles in chromatin regulation
2. A role for SUMO in nucleotide excision repair
3. Deficient SUMO attachment to flp recombinase leads to homologous recombination-dependent hyperamplification of the yeast 2 μm circle plasmid
4. Ubc9 Sumoylation Regulates SUMO Target Discrimination
5. Ubiquitin-dependent proteolytic control of SUMO conjugates
6. Topoisomerase I-dependent viability loss in Saccharomyces cerevisiae mutants defective in both SUMO conjugation and DNA repair
7. Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae
8. Multiple domains in Siz SUMO ligases contribute to substrate selectivity
9. Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
10. Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies
11. Sumoylation of the yeast Gcn5 protein
12. Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage
13. Misregulation of 2μm circle copy number in a SUMO pathway mutant
14. Varshavsky's contributions [3]
15. Global analysis of protein sumoylation in Saccharomyces cerevisiae
16. Protein modification by SUMO
17. The SUMO Isopeptidase Ulp2 Prevents Accumulation of SUMO Chains in Yeast
18. Ubiquitin branches out
19. An E3-like factor that promotes SUMO conjugation to the yeast septins
20. SUMO conjugation and deconjugation

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