James H. Keen, PhD

Contact Dr. Keen

233 South 10th Street
Suite 915
Philadelphia, PA 19107

(215) 503-4624
(215) 923-0622 fax

Research & Clinical Interests
The long-term goal of my lab has been an understanding of the structure of clathrin-coated membranes and their role in membrane transport processes within mammalian cells. It is well established that plasma

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Publications

Most recent Peer-reviewed Publications

1. Arf6 regulation of Gyrating-Clathrin
2. GGA3 functions as a switch to promote met receptor recycling, essential for sustained ERK and cell migration
3. Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes
4. Gyrating clathrin: Highly dynamic clathrin structures involved in rapid receptor recycling
5. Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2
6. Phosphoinositide 3-kinase C2α links clathrin to microtubule-dependent movement
7. Dynamics of membrane clathrin-coated structures during cytokinesis
8. Individual phosphoinositide 3-kinase C2α domain activities independently regulate clathrin function
9. Membrane targeting of endocytic adaptors: Cargo and lipid do it together
10. Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: Implications for antigen presentation to cytotoxic T lymphocytes
11. The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4
12. A glimpse of coated vesicle creation? Well almost!
13. G protein-coupled receptor/arrestin3 modulation of the endocytic machinery
14. The actin-binding protein Hip1R associates with clathrin during early stages of endocytosis and promotes clathrin assembly in vitro
15. The class II phosphoinositide 3-kinase C2α is activated by clathrin and regulates clathrin-mediated membrane trafficking
16. Selective recruitment of arrestin-3 to clathrin coated pits upon stimulation of G protein-coupled receptors
17. The class II phosphoinositide 3-kinase PI3K-C2α is concentrated in the trans-Golgi network and present in clathrin-coated vesicles
18. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits
19. Acute cholesterol depletion inhibits clathrin-coated pit budding
20. Spatial control of coated-pit dynamics in living cells

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