Karen E. Knudsen, PhD

Contact Dr. Knudsen

233 South 10th Street
Suite 1008
Philadelphia, PA 19107

(215) 503-8574
fax

Research and Clinical Interests
Translational prostate cancer research, cell cycle control, hormonal control of gene transcription, chromatin remodeling.

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Publications

Most recent Peer-reviewed Publications

1. The role of tumor suppressor dysregulation in prostate cancer progression
2. Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes
3. Dual roles of PARP-1 promote cancer growth and progression
4. Cyclin D1 goes metabolic: Dual functions of cyclin D1 in regulating lipogenesis
5. The AR dependent cell cycle: Mechanisms and cancer relevance
6. Targeting pioneering factor and hormone receptor cooperative pathways to suppress tumor progression
7. mTOR is a selective effector of the radiation therapy response in androgen receptor-positive prostate cancer
8. Postprostatectomy radiation therapy: An evidence-based review
9. FOXA1: Master of steroid receptor function in cancer
10. Time to stratify? the retinoblastoma protein in castrate-resistant prostate cancer
11. Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate
12. The meaning of p16 ink4a expression in tumors: Functional significance, clinical associations and future developments
13. Therapeutically activating RB: Reestablishing cell cycle control in endocrine therapy-resistant breast cancer
14. Outsmarting androgen receptor: Creative approaches for targeting aberrant androgen signaling in advanced prostate cancer
15. Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function
16. A tale of three PKCs: Epsilon emerges as a driver of pre-neoplastic phenotypes
17. The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression
18. RB-pathway disruption in breast cancer: Differential association with disease subtypes, disease-specific prognosis and therapeutic response
19. Identification of ASF/SF2 as a critical, allele-specific effector of the cyclin D1b oncogene
20. Partners in crime: Deregulation of AR activity and androgen synthesis in prostate cancer

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