My Mahoney, PhD

Contact Dr. Mahoney

233 South 10th Street
Room 428
Philadelphia, PA 19107

(215) 503-4632
(215) 923-1098 fax

Research and Clinical Interests
Roles of desmosomal proteins in regulating epithelial cell adhesion, growth and survival; deregulation of desmosomal proteins in autoimmune, infectious, and inherited diseases associated with fragility and abnormality in diverse tissues such as the skin, hair and heart; mechanisms by which desmosomal cadherins can modulate mitogenic signaling pathways; genetically manipulated animal models to study human diseases.

Publications

Most recent Peer-reviewed Publications

1. Expression of p53 Protein After Nonablative Rejuvenation: The Other Side of the Coin
2. Efficacy of mesotherapy in facial rejuvenation: A histological and immunohistochemical evaluation
3. Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca 2+/Mn 2+ ATPase SPCA1 in cultured keratinocytes
4. Multiple minimally invasive Erbium: Yttrium Aluminum Garnet laser mini-peels for skin rejuvenation: An objective assessment
5. A role for caveolin-1 in desmoglein binding and desmosome dynamics
6. Noncanonical Hedgehog Signaling
7. Effects of the Nd:YAG 1320-nm laser on skin rejuvenation: Clinical and histological correlations
8. Radiofrequency facial rejuvenation: Evidence-based effect
9. Electro-optical synergy technique a new and effective nonablative approach to skin aging
10. Compound heterozygous desmoplakin mutations result in a phenotype with a combination of myocardial, skin, hair, and enamel abnormalities
11. Extracellular matrix in cutaneous ageing: The effects of 0.1% copper-zinc malonate-containing cream on elastin biosynthesis
12. Increased expression of Dsg2 in malignant skin carcinomas: A tissue-microarray based study
13. Deregulation of keratinocyte differentiation and activation: A hallmark of venous ulcers (Journal of Cellular and Molecular Medicine (2008) 12, 6B, (2675-2690)
14. Deregulation of keratinocyte differentiation and activation: A hallmark of venous ulcers
15. Decreased plakophilin-1 expression promotes increased motility in head and neck squamous cell carcinoma cells
16. Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes
17. Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just 'witnesses of disease'?
18. Controversies in Experimental Dermatology: Viewpoint 7
19. Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle
20. Delineation of diversified desmoglein distribution in stratified squamous epithelia: Implications in diseases

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