Timothy L. Manser, PhD

Contact Dr. Manser

233 South 10th Street
302 BLSB
Philadelphia, PA 19107

(215) 503-4672
(215) 923-4153 fax

Research and Clinical Interests
Our laboratory's interests center on the antigen-dependent stages of B cell differentiation in the mouse, leading to the generation of B cell memory and the control of B cell autoreactivity.

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Publications

Most recent Peer-reviewed Publications

1. Cutting edge: Macrophages are required for localization of antigen-activated b cells to the follicular perimeter and the subsequent germinal center response
2. A germline-competent embryonic stem cell line from NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice
3. Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing
4. Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever
5. Immunologic research at Thomas Jefferson University: A recent history
6. Human immune system mi Current potential and limitations for translational research on human antibody responses
7. Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments
8. Expression of cellular FLIP by B cells is required for their participation in an immune response
9. Germinal center reutilization by newly activated B cells
10. The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints
11. Initial Clonal Expansion of Germinal Center B Cells Takes Place at the Perimeter of Follicles
12. Influence of B cell antigen receptor expression level on pathways of B cell tolerance induction
13. A role for cFLIP in B cell proliferation and stress MAPK regulation
14. Specialization and Complementation of Humoral Immune Responses to Infection: Preface
15. Influence of fas on the regulation of the response of an anti-nuclear antigen B cell clonotype to foreign antigen
16. Primary development and participation in a foreign antigen-driven immune response of a chromatin-reactive B cell clonotype are not influenced by TLR9 or other MyD88-dependent TLRs
17. Expression of the autoimmune Fcgr2b NZW allele fails to be upregulated in germinal center B cells and is associated with increased IgG production
18. Quantitatively reduced participation of anti-nuclear antigen B cells that down-regulate B cell receptor during primary development in the germinal center/memory B cell response to foreign antigen
19. Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor loci
20. FcγRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity

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