Alexander M. Mazo, PhD

Contact Dr. Mazo

1020 Locust Street
JAH, Room 485
Philadelphia, PA 19107

(215) 503-4785
(215) 923-7144 fax

Research and Clinical Interests
Transcriptional Regulation by Epigenetic Factors and Nuclear Hormone Receptors

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Publications

Most recent Peer-reviewed Publications

1. Ash2 acts as an ecdysone receptor coactivator by stabilizing the histone methyltransferase Trr
2. TrxG and PcG proteins but not methylated histones remain associated with DNA through replication
3. Ecdysone- and NO-Mediated Gene Regulation by Competing EcR/Usp and E75A Nuclear Receptors during Drosophila Development
4. Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation
5. Regulatory noncoding RNAs at Hox loci
6. Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
7. Transcriptional interferen An unexpected layer of complexity in gene regulation
8. Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth
9. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos
10. Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional Interference
11. A motif within SET-domain proteins binds single-stranded nucleic acids and transcribed and supercoiled DNAs and can interfere with assembly of nucleosomes
12. ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia
13. Purification and Biochemical Properties of the Drosophila TAC1 Complex
14. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex
15. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila
16. Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements
17. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation
18. Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene
19. huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions
20. Self-association of the SET domains of human ALL-1 and of Drosophila TRITHORAX and ASH1 proteins

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