James P McGettigan, PhD

Contact Dr. McGettigan

1020 Locust Street
JAH 466
Philadelphia, PA 19107

(215) 503-4629
(215) 923-7144 fax

Research and Clinical Interests
The World Health Organization and the Global Alliance for Vaccines and Immunizations report that almost 27 million people do not receive vaccines that are available and needed.

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Publications

Most recent Peer-reviewed Publications

1. Investigating the Role for IL-21 in Rabies Virus Vaccine-induced Immunity
2. Experimental rabies vaccines for humans
3. Characterization of a single-cycle rabies virus-based vaccine vector
4. The cell biology of rabies virus: Using stealth to reach the brain
5. Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIVmac251 challenge
6. Replication-deficient rabies virus-based vaccines are safe and immunogenic in mice and nonhuman primates
7. Interferon-β expressed by a rabies virus-based HIV-1 vaccine vector serves as a molecular adjuvant and decreases pathogenicity
8. Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene
9. Infection of monocytes or immature dendritic cells (DCs) with an attenuated rabies virus results in DC maturation and a strong activation of the NFκB signaling pathway
10. Highly attenuated rabies virus-based vaccine vectors expressing simian-human immunodeficiency virus89.6P Env and simian immunodeficiency virusmac239 Gag are safe in rhesus macaques and protect from an AIDS-like disease
11. A single immunization with a recombinant canine adenovirus expressing the rabies virus G protein confers protective immunity against rabies in mice
12. Rabies virus glycoprotein as a carrier for anthrax protective antigen
13. siRNA targeting Vaccinia virus double-stranded RNA binding protein [E3L] exerts potent antiviral effects
14. Enhanced humoral HIV-1-specifc immune responses generated from recombinant rhabdoviral-based vaccine vectors co-expressing HIV-1 proteins and IL-2
15. Insect renal tubules constitute a cell-autonomous immune system that protects the organism against bacterial infection
16. Strong cellular and humoral anti-HIV Env immune responses induced by a heterologous rhabdoviral prime-boost approach
17. Conservation of capa peptide-induced nitric oxide signalling in Diptera
18. Rabies virus nucleoprotein as a carrier for foreign antigens
19. Erratum: Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TSG101 and VPS4A (Journal of Virology (2004) 78, 6 (2657-2665))
20. Budding of PPxY-Containing Rhabdoviruses Is Not Dependent on Host Proteins TGS101 and VPS4A

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