Steven McKenzie, PhD

Contact Dr. McKenzie

1015 Walnut Street
Room 702
Philadelphia, PA 19107

(215) 955-3900
(215) 955-4050 fax

Research and Clinical Interests
Murine models of immune-mediated thrombocytopenia and thrombosis syndromes;

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Publications

Most recent Peer-reviewed Publications

1. Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo
2. The complex transcriptional landscape of the anucleate human platelet
3. Monocytes in HIT: An evolving story
4. CalDAG-GEFI deficiency protects mice in a novel model of FcγRIIA-mediated thrombosis and thrombocytopenia
5. Safety and pharmacokinetics of subcutaneously administered recombinant activated factor VII (rFVIIa)
6. PRT-060318, a novel Syk inhibitor, prevents heparin-induced thrombocytopenia and thrombosis in a transgenic mouse model
7. Amelioration of murine immune thrombocytopenia by CD44 antibodies: A potential therapy for ITP?
8. Dominant expression of the inhibitory FcγRIIB prevents antigen presentation by murine plasmacytoid dendritic cells
9. The clot thickens (or not)
10. Thrombopoietin following transfusion of platelets in preterm neonates
11. The yin and yang of Fcγ receptors in ITP
12. Heparin-induced thrombocytopenia: An autoimmune disorder regulated through dynamic autoantigen assembly/disassembly
13. Cholesterol enrichment of human monocyte/macrophages induces surface exposure of phosphatidylserine and the release of biologically-active tissue factor-positive microvesicles
14. Prothrombotic factors enhance heparin-induced thrombocytopenia and thrombosis in vivo in a mouse model
15. Platelet FcγRIIA binds and internalizes IgG-containing complexes
16. Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcγ receptor IIa-transgenic mice
17. PF4/heparin complexes are T cell-dependent antigens
18. A novel human CD32 mAb blocks experimental immune haemolytic anaemia in FcγRIIA transgenic mice
19. Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia
20. Heparin-induced thrombocytopenia and other immune thrombocytopenias: Lessons from mouse models

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