Steven B. McMahon, PhD

Contact Dr. McMahon

233 South 10th Street
Suite 609
Philadelphia, PA 19107

(215) 503-9064
fax

Research and Clinical Interests
Our group has a long-standing interest in understanding the biochemical events that are deregulated to cause alterations in broad transcriptional programs in human cancer.

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Publications

Most recent Peer-reviewed Publications

1. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex
2. Dynamic regulation of mitochondrial transcription as a mechanism of cellular adaptation
3. MYST protein acetyltransferase activity requires active site lysine autoacetylation
4. Inhibition of the single downstream target BAG1 activates the latent apoptotic potential of MYC
5. Enzymatic assays for assessing histone deubiquitylation activity
6. Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53
7. Myc overexpression brings out unexpected antiapoptotic effects of miR-34a
8. Regulation of microRNA-145 by growth arrest and differentiation
9. Deacetylation of the DNA-binding domain regulates p53-mediated apoptosis
10. Emerging concepts in the analysis of transcriptional targets of the MYC oncoprotein: Are the targets targetable?
11. Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
12. Rise of the rival
13. Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells
14. hMOF, a KAT(8) with Many Lives
15. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
16. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
17. The p53 family and programmed cell death
18. Control of nucleotide biosynthesis by the MYC oncoprotein
19. USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A
20. The Putative Cancer Stem Cell Marker USP22 Is a Subunit of the Human SAGA Complex Required for Activated Transcription and Cell-Cycle Progression

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