Dr. Mercier Isabelle Mercier, PhD

Contact Dr. Mercier

233 South 10th Street
Room 939
Philadelphia, PA 19107

(215) 503-9288

Research and Clinical Interests
Understanding Hormone-Refractory Cancers (HRC)

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Most recent Peer-reviewed Publications

  1. CAPER, a novel regulator of human breast cancer progression
  2. Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development
  3. Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide
  4. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: Chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug
  5. Warburg meets autophagy: Cancer-Associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis
  6. Caveolin-1 and breast cancer: A new clinical perspective
  7. Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate
  8. Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction
  9. Role of cholesterol in the development and progression of breast cancer
  10. The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox
  11. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
  12. Clinical and translational implications of the caveolin gene family: Lessons from mouse models and human genetic disorders
  13. Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy
  14. Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation
  15. Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature
  16. Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions
  17. Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts
  18. Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation
  19. Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy
  20. ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer

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