Isabelle Mercier, PhD

Contact Dr. Mercier

233 South 10th Street
Room 939
Philadelphia, PA 19107

(215) 503-9288
fax

Research and Clinical Interests
Understanding Hormone-Refractory Cancers (HRC)

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Publications

Most recent Peer-reviewed Publications

1. Caveolin-1 and accelerated host aging in the breast tumor microenvironment: Chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug
2. Warburg meets autophagy: Cancer-Associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis
3. Caveolin-1 and breast cancer: A new clinical perspective
4. Caveolin-1 overexpression enhances androgen-dependent growth and proliferation in the mouse prostate
5. Caveolin-1 deficiency exacerbates cardiac dysfunction and reduces survival in mice with myocardial infarction
6. Role of cholesterol in the development and progression of breast cancer
7. The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox
8. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
9. Clinical and translational implications of the caveolin gene family: Lessons from mouse models and human genetic disorders
10. Towards a new "stromal-based" classification system for human breast cancer prognosis and therapy
11. Using Caveolin-1 epithelial immunostaining patterns to stratify human breast cancer patients and predict the Caveolin-1 (P132L) mutation
12. Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature
13. Genetic ablation of caveolin-1 drives estrogen-hypersensitivity and the development of DCIS-like mammary lesions
14. Caveolin-1-/- null mammary stromal fibroblasts share characteristics with human breast cancer-associated fibroblasts
15. Loss of caveolin-3 induces a lactogenic microenvironment that is protective against mammary tumor formation
16. Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy
17. ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer
18. Caveolin-1 deficiency increases cerebral ischemic injury
19. Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers
20. Stromal and epithelial caveolin-1 both confer a protective effect against mammary hyperplasia and tumorigenesis: Caveolin-1 antagonizes cyclin D1 function in mammary epithelial cells

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