Dr. Morrione Andrea Morrione, PhD

Contact Dr. Morrione

233 South 10th Street
Suite 620
Philadelphia, PA 19107

(215) 503-4519
(215) 923-0249 fax

Research and Clinical Interests
Characterization of Insulin-like Growth Factor Receptor I (IGF-IR) and IR-A (insulin receptor isoform A) function in bladder cancer initiation and progression. Role of the growth factor progranulin (proepithelin) and its receptor in bladder cancer. Characterization of the role of adaptor protein Grb10 in the regulation of IGF-IR and IR-A ubiquitination, trafficking, and signaling.

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Publications

Most recent Peer-reviewed Publications

  1. Growth of v-src-transformed cells in serum-free medium through the induction of growth factors
  2. β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1
  3. Dichotomy of decorin activity on the insulin-like growth factor-I system
  4. Proline-rich tyrosine kinase 2 (Pyk2) regulates IGF-I-induced cell motility and invasion of urothelial carcinoma cells
  5. Insulin and insulin-like growth factor II differentially regulate endocytic sorting and stability of insulin receptor isoform A
  6. Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells
  7. Decorin antagonizes IGF receptor I (IGF-IR) function by interfering with IGF-IR activity and attenuating downstream signaling
  8. Mitostatin is down-regulated in human prostate cancer and suppresses the invasive phenotype of prostate cancer cells
  9. Mutual interaction and reciprocal down-regulation between c-met and insulin receptor substrate-1
  10. The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin
  11. Proepithelin is an autocrine growth factor for bladder cancer
  12. Proepithelin regulates prostate cancer cell biology by promoting cell growth, migration, and anchorage-independent growth
  13. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer
  14. Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization
  15. Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex
  16. Phosphatidylinositol 3-kinase p85α subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: Molecular mechanisms and biological consequences
  17. p27Kip1-stathmin interaction influences sarcoma cell migration and invasion
  18. Grb10 Adapter Protein as Regulator of Insulin-Like Growth Factor Receptor Signaling
  19. The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor
  20. Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor

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