Marja Nevalainen, MD, PhD

Contact Dr. Nevalainen

233 South 10th Street
Suite 309A
Philadelphia, PA 19107

(215) 503-9250
(215) 503-9245 fax

Research and Clinical Interests
Stat transcription factors in prostate cancer.

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Publications

Most recent Peer-reviewed Publications

1. STAT5A/B Gene Locus Undergoes Amplification during Human Prostate Cancer Progression
2. Nuclear Stat5a/b predicts early recurrence and prostate cancer-specific death in patients treated by radical prostatectomy
3. Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity
4. Reply to A. Italiano
5. Prolactin regulation of the prostate gland: A female player in a male game
6. Prolactin regulation of the prostate gland: a female player in a male game
7. Signal transducer and activator of transcription 5a/b: Biomarker and therapeutic target in prostate and breast cancer
8. Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure
9. Targeting transcription factor stat5a/b as a therapeutic strategy for prostate cancer
10. N-terminal truncation of Stat5a/b circumvents PIAS3-mediated transcriptional inhibition of Stat5 in prostate cancer cells
11. Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer
12. Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo
13. Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth
14. Transcription factor Stat5a/b as a therapeutic target protein for prostate cancer
15. Androgen-regulated and highly tumorigenic human prostate cancer cell line established from a transplantable primary CWR22 tumor
16. Signal transducer and activator of transcription 5A/B in prostate and breast cancers
17. Stat3 promotes metastatic progression of prostate cancer
18. Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo
19. Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells
20. Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway

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