Research and Clinical Interests
Molecular mechanisms of phagocytosis: how do pathogens subvert this process?
*Unraveling membrane trafficking involved in the phagocytic pathway and its regulation
*how do intracellular bacteria interfere with the host phagocytic system to escape lysosomal degradation?
Do intracellular bacteria commonly use snare-like proteins to manipulate the host membrane fusion?
*Screening salmonella and legionella genomes
*study the inhibitory effect of potential snare-like bacterial proteins
Characterization of eukaryotic membrane fusion machinery
*identification and characterization of primitive membrane fusion machineries (similar to snare proteins)
*characterization of the specificity of fusion encoded in the snare proteins
*characterization of intramolecular snare regulation
Study of the phagocytic mechanism in mast cells, one of the main players in allergy