Natalia A. Riobo, PhD

Contact Dr. Riobo

233 South 10th Street
BLSB 922
Philadelphia, PA 19107

(215) 503-8549
(215) 923-1098 fax

Research and Clinical Interests
Signal transduction mechanisms employed by mammalian Hedgehog proteins in cardiomyoctes, endothelium, cancer cells and stromal fibroblasts in the context of cardiovascular regenerative medicine and cancer.

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Publications

Most recent Peer-reviewed Publications

1. Smoothened is a fully competent activator of the heterotrimeric g protein gi
2. Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer
3. The hedgehog signal transduction network
4. Noncanonical Hedgehog Signaling
5. Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to G i proteins
6. The α subunit of the G protein G 13 regulates activity of one or more gli transcription factors independently of smoothened
7. Heterotrimeric Gi proteins link hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration
8. Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways
9. Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation after cardiac arrest.
10. Chapter 11 Purification and Bioassay of Hedgehog Ligands for the Study of Cell Death and Survival
11. Pathways of signal transduction employed by vertebrate Hedgehogs
12. Androgens regulate protein kinase Cδ transcription and modulate its apoptotic function in prostate cancer cells
13. Activation of heterotrimeric G proteins by Smoothened
14. Hedgehog signal transduction: Signal integration and cross talk in development and cancer
15. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
16. Protein kinase C-δ and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
17. Receptors coupled to heterotrimeric G proteins of the G12 family
18. Neuronal nitric oxide synthases in brain and extraneural tissues
19. The modulation of mitochondrial nitric-oxide synthase activity in rat brain development
20. Neuroprotection in Parkinson's disease; a commentary

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