Michael Root, MD, PhD

Contact Dr. Root

233 South 10th Street
Room 802
Philadelphia, PA 19107

(215) 503-4564
(215) 923-2117 fax

Research and Clinical Interests
Structure and function of glycoproteins involved in viral and cell-cell membrane fusion; design of viral entry inhibitors and immunogens for vaccine development; antibody-antigen interactions.

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Publications

Most recent Peer-reviewed Publications

1. Polyvalent side chain peptide-synthetic polymer conjugates as HIV-1 entry inhibitors
2. Nucleoporin Nup50 stabilizes closed conformation of armadillo repeat 10 in importin α5
3. Design of a potent D-peptide HIV-1 entry inhibitor with a strong barrier to resistance
4. Asymmetric deactivation of HIV-1 gp41 following fusion inhibitor binding
5. Interactions of HIV-1 inhibitory peptide T20 with the gp41 N-HR coiled coil
6. Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection
7. Neutralization of Botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain
8. Hybridoma populations enriched for affinity-matured human IgGs yield high-affinity antibodies specific for botulinum neurotoxins
9. A human monoclonal antibody that binds serotype A botulinum neurotoxin
10. C34, a membrane fusion inhibitor, blocks HIV infection of Langerhans cells and viral transmission to T cells
11. Kinetic dependence to HIV-1 entry inhibition
12. HIV-1 gp41 as a target for viral entry inhibition
13. Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein
14. Protein design of an HIV-1 entry inhibitor