Michael Root, MD, PhD

Contact Dr. Root

233 South 10th Street
Room 802
Philadelphia, PA 19107

(215) 503-4564
(215) 923-2117 fax

Research and Clinical Interests
Multiple Sclerosis is an autoimmune disease of the central nervous system that affects over 400,000 Americans and over 2 million worldwide.

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Publications

Most recent Peer-reviewed Publications

1. Intravenous transfer of apoptotic cell-treated dendritic cells leads to immune tolerance by blocking Th17 cell activity
2. Immune tolerance induced by intravenous transfer of immature dendritic cells via up-regulating numbers of suppressive IL-10+ IFN-γ+-producing CD4+ T cells
3. Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination
4. Generation of large numbers of highly purified dendritic cells from bone marrow progenitor cells after co-culture with syngeneic murine splenocytes
5. Independent and interdependent immunoregulatory effects of IL-27, IFN-β, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis
6. Low dose zymosan ameliorates both chronic and relapsing experimental autoimmune encephalomyelitis
7. Role of serine proteases in inflammation: Bowman-Birk protease inhibitor (BBI) as a potential therapy for autoimmune diseases
8. Accelerated and enhanced effect of CCR5-transduced bone marrow neural stem cells on autoimmune encephalomyelitis
9. TCR stimulation upregulates MS4a4B expression through induction of AP-1 transcription factor during T cell activation
10. CNS-specific therapy for ongoing EAE by silencing IL-17 pathway in astrocytes
11. Intravenous tolerance effectively overcomes enhanced pro-inflammatory responses and experimental autoimmune encephalomyelitis severity in the absence of IL-12 receptor signaling
12. IL-10 deficiency blocks the ability of LPS to regulate expression of tolerance-related molecules on dendritic cells
13. Interleukin-10 plays a crucial role in suppression of experimental autoimmune encephalomyelitis by Bowman-Birk inhibitor
14. Bowman-Birk inhibitor attenuates experimental autoimmune encephalomyelitis by delaying infiltration of inflammatory cells into the CNS
15. Generation of immunogenic and tolerogenic clinical-grade dendritic cells
16. IL-9 is important for T-cell activation and differentiation in autoimmune inflammation of the central nervous system
17. Kit (W-sh) mice develop earlier and more severe experimental autoimmune encephalomyelitis due to absence of immune suppression
18. The encephalitogenicity of TH 17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
19. 3G11 expression in CD4+ T cell-mediated autoimmunity and immune tolerance
20. Oral resveratrol reduces neuronal damage in a model of multiple sclerosis

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