Research and Clinical Interests
Multiple Sclerosis is an autoimmune disease of the central nervous system
that affects over 400,000 Americans and over 2 million worldwide.
My research focuses on the pathogenesis of multiple sclerosis using the animal
model of this disease, experimental autoimmune encephalomyelitis (EAE). At
the present, we are focusing on three main areas:
1) The role of IL-12/IL-17/IL-23 axis in the pathogenesis of EAE and
Specifically, studies will examine IL-12/IL-17/IL-23 produced by antigen
presenting cells (APC) from the periphery (macrophages and dendritic cells)
and from the central nervous system (CNS) microglia in EAE. In addition to a
better understanding of the pathogenesis of inflammatory demyelination, the
information derived from this study will be helpful if these cytokines are
to be considered as targets for therapy in MS.
2) The effect of the Bowman-Birk protease inhibitor on the course of EAE.
This study has the potential to provide a novel, safe, and effective therapy
for multiple sclerosis.
3) Mechanisms of intravenous tolerance in EAE.
This study will elucidate the mechanisms by which intravenous myelin
antigens induce tolerance and suppress clinical disease in EAE. This study
will provide a novel method for analyzing the migration and functional
status of infiltrating cells in the CNS, in particular, and in target organs
of other autoimmune diseases. It has the potential as a possible therapy for