Luis Sigal, DVM, PhD

Contact Dr. Sigal

333 Cottman Avenue
Fox Chase Cancer Center W260
Philadelphia, PA 19111

(215) 728-7061
(215) 728-2412 fax

Research and Clinical Interests
Antigen presentation in viral infections and mechanisms of natural and acquired resistance to ectromelia virus.

Publications

Most recent Peer-reviewed Publications

1. Immunology: Memory cells sound the alarm
2. Memory CD8+ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection
3. Getting in front and behind the enemy lines to counter virus infection
4. Characterization of ectromelia virus deficient in EVM036, thehomolog of vaccinia virus F13l, and its application for rapid generation of recombinant viruses
5. Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease
6. Perforin-dependent CD4 + T-cell cytotoxicity contributes to control a murine poxvirus infection
7. Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver
8. Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8 + T cell response
9. CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease
10. Development and function of CD94-deficient natural killer cells
11. Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking
12. Studying NK cell responses to ectromelia virus infections in mice.
13. Direct presentation is sufficient for an efficient anti-viral CD8 + T cell response
14. The amino acid sequences flanking an antigenic determinant can strongly affect MHC class I cross-presentation without altering direct presentation
15. Enhanced NK-cell development and function in BCAP-deficient mice
16. The orthopoxvirus type I IFN binding protein is essential for virulence and an effective target for vaccination
17. A role for NKG2D in NK cell-mediated resistance to poxvirus disease
18. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection
19. Direct CD28 costimulation is required for CD8+ T cell-mediated resistance to an acute viral disease in a natural host
20. Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host

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