Linda D. Siracusa, PhD

Contact Dr. Siracusa

233 South 10th Street
BLSB 719
Philadelphia, PA 19107

(215) 503-4536
(215) 923-4153 fax

Research and Clinical Interests
The study of genes that influence complex traits is a rapidly evolving field.

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Publications

Most recent Peer-reviewed Publications

1. Identification of five novel modifier loci of Apc Min harbored in the BXH14 recombinant inbred strain
2. Tpl2 ablation promotes intestinal inflammation and tumorigenesis in Apcmin mice by inhibiting IL-10 secretion and regulatory T-cell generation
3. Technical approaches for mouse models of human disease
4. Identification of Mom12 and Mom13, two novel modifier loci of Apc Min-mediated intestinal tumorigenesis
5. The armadillo repeat domain of Apc suppresses intestinal tumorigenesis
6. A Tcf4-GFP reporter mouse model for monitoring effects of Apc mutations during intestinal tumorigenesis
7. Cancer-associated genomic regions (CAGRs) and noncoding RNAs: Bioinformatics and therapeutic implications
8. The noncoding RNAs: A genomic symphony of transcripts
9. Influence of a nonfragile FHIT transgene on murine tumor susceptibility
10. Guanylyl Cyclase C Suppresses Intestinal Tumorigenesis by Restricting Proliferation and Maintaining Genomic Integrity
11. MicroRNA genes are frequently located near mouse cancer susceptibility loci
12. The modifier of Min 2 (Mom2) locus: Embryonic lethality of a mutation in the Atp5a1 gene suggests a novel mechanism of polyp suppression
13. Mammalian microRNAs: A small world for fine-tuning gene expression
14. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice
15. Diversity in secreted PLA2-IIA activity among inbred mouse strains that are resistant or susceptible to ApcMin/+ tumorigenesis
16. A role for the androgen receptor in collagen content of the skin
17. Analysis of reciprocal congenic lines reveals the C3H/HeJ genome to be highly resistant to Apc Min intestinal tumorigenesis
18. The Collaborative Cross, a community resource for the genetic analysis of complex traits
19. Skeletal dysplasia and male infertility locus on mouse chromosome 9
20. The nature and identification of quantitative trait loci: A community's view

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