Christopher M. Snyder, PhD

Contact Dr. Snyder

233 South 10th Street
Bluemle Life Sciences Building 526
Philadelphia, PA 19107

(215) 503-2543
fax

Research and Clinical Interests
Our lab is interested in understanding how T cells respond to chronic antigen stimulation

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Publications

Most recent Peer-reviewed Publications

1. Competition between T cells maintains clonal dominance during memory inflation induced by MCMV
2. Competition for antigen at the level of the APC is a major determinant of immunodominance during memory inflation in murine cytomegalovirus infection
3. Editorial: Once more unto the breach, dear friends: CMV reactivates when the walls come down
4. Buffered memory: A hypothesis for the maintenance of functional, virus-specific CD8 + T cells during cytomegalovirus infection
5. Sustained CD8+ T cell memory inflation after infection with a single-cycle Cytomegalovirus
6. Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide
7. Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells
8. CD4+ T cell help has an epitope-dependent impact on CD8 + T cell memory inflation during murine cytomegalovirus infection
9. Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells
10. GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi
11. Cis-Golgi matrix proteins move directly to endoplasmic reticulum exit sites by association with tubules
12. Activation and tolerance in CD4+ T cells reactive to an immunoglobulin-variable region
13. Negligible class II MHC presentation of B cell receptor-derived peptides by high density resting B cells
14. Somatic origin of T-cell epitopes within antibody variable regions: Significance to monoclonal therapy and genesis of systemic autoimmune disease