Yuri K. Sykulev, MD, PhD

Contact Dr. Sykulev

233 South 10th Street
Bluemle Life Sciences Building 706
Philadelphia, PA 19107

(215) 503-4530
(215) 923-4153 fax

Research and Clinical Interests
The major goal of my research program is to understand molecular mechanisms

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Publications

Most recent Peer-reviewed Publications

1. Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling
2. Enteric alpha defensins in norm and pathology.
3. The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex
4. Enteric alpha defensins in norm and pathology
5. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes
6. Quantum dots as a unique nanoscaffold to mimic membrane receptor clustering
7. T cell receptor signaling kinetics takes the stage
8. A novel composite immunotoxin that suppresses rabies virus production by the infected cells
9. Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation
10. Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain
11. Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?
12. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide
13. Protein kinase Cθ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
14. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
15. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response
16. Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes
17. Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope
18. ICAM-1 co-stimulates target cells to facilitate antigen presentation
19. Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes
20. Major histocompatibility complex class I-intercellular adhesion molecule-1 association on the surface of target cells: Implications for antigen presentation to cytotoxic T lymphocytes

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