Dr. Sykulev Yuri K. Sykulev, MD, PhD

Contact Dr. Sykulev

233 South 10th Street
Bluemle Life Sciences Building 706
Philadelphia, PA 19107

(215) 503-4530
(215) 923-4153 fax

Research and Clinical Interests
The major goal of my research program is to understand molecular mechanisms

Show Details


Most recent Peer-reviewed Publications

  1. Integrin receptors on tumor cells facilitate NK cell-mediated antibody-dependent cytotoxicity
  2. Evidence that the density of self peptide-MHC ligands regulates T-cell receptor signaling
  3. Enteric alpha defensins in norm and pathology.
  4. The mechanisms of inactivation of the Tag7-Hsp70 cytotoxic complex
  5. Enteric alpha defensins in norm and pathology
  6. Mechanisms controlling granule-mediated cytolytic activity of cytotoxic T lymphocytes
  7. Quantum dots as a unique nanoscaffold to mimic membrane receptor clustering
  8. T cell receptor signaling kinetics takes the stage
  9. A novel composite immunotoxin that suppresses rabies virus production by the infected cells
  10. Changing separating distances between immune receptors as a sensitive mechanism regulating T-cell activation
  11. Kinetics of Early T Cell Receptor Signaling Regulate the Pathway of Lytic Granule Delivery to the Secretory Domain
  12. Can oligomeric T-cell receptor be used as a tool to detect viral peptide epitopes on infected cells?
  13. How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide
  14. Protein kinase Cθ regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL
  15. Tpl2 and ERK transduce antiproliferative T cell receptor signals and inhibit transformation of chronically stimulated T cells
  16. Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response
  17. Structural basis for degenerate recognition of natural HIV peptide variants by cytotoxic lymphocytes
  18. Target Cell Contributions to Cytotoxic T Cell Sensitivity
  19. Antagonism of HIV-specific CD4+ T cells by C-terminal truncation of a minimum epitope
  20. ICAM-1 co-stimulates target cells to facilitate antigen presentation

View All Publications