Dr. Uitto Jouni J. Uitto, MD, PhD

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233 South 10th Street
Room 450
Philadelphia, PA 19107

(215) 503-5785
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Research and Clinical Interests
Jouni Uitto, MD, PhD, has been professor of dermatology and cutaneous biology, and biochemistry and molecular biology, and chair of the Department of Dermatology and Cutaneous Biology at Jefferson Medical College, in Philadelphia, Pennsylvania, since 1986.  He is also Director of the Jefferson Institute of Molecular Medicine at Thomas Jefferson University. He received his MD and PhD degrees from the University of Helsinki, Finland, and completed his residency training in dermatology at Washington University School of Medicine, St. Louis, Missouri.

Dr Uitto is internationally recognized for his research on connective tissue biochemistry and molecular biology in relation to cutaneous diseases and skin aging. Dr Uitto's publications include 610 original articles in peer-reviewed journals, 285 textbook chapters and review articles, and 907 abstracts on presentations at national and international meetings.

Dr Uitto has been the recipient of numerous national and international awards, including a Research Career Development Award from the National Institutes of Health, the Distinguished Service Award from the Dystrophic Epidermolysis Bullosa Research Association of America, the William Montagna Lectureship Award from the Society for Investigative Dermatology, the Hermann Pinkus as well as Elson B. Helwig Memorial Lectureship Awards from the American Society of Dermatopathology, the Earl of Litchfield Lectureship Award of Oxford University, The Dohi Memorial Lectureship Award from the Japanese Dermatological Society, and the Kung-Sun Oh Memorial Lectureship from Yonsei University, Seoul, Korea. In 1993, he was selected as the recipient of the Marion B. Sulzberger Memorial Award and Lectureship and was designated as the "Professor of the Year" by the American Academy of Dermatology. Dr Uitto has been awarded the prestigious Matti Äyräpää Lectureship, the highest physician-scientist award in his native country, Finland. In 1996, Dr Uitto was appointed as Anglo-American Visiting Professor of the Royal Society of Medicine, London, United Kingdom. Most recently, he was the recipient of the first SID Kligman/Frost Leadership Award presented at IID, Kyoto, Japan. He has received an Honorary Doctorate in Medicine from the University of Kuopio, the University of Oulu, and the University of Turku, Finland, as well as the Honorary Professor title from China Medical University, and Honorary Visiting Professor from the University of Helsinki.

Dr. Uitto has held office in several scientific and professional societies, including President of the Society for Investigative Dermatology, President and Chairman of the Board of Trustees, the Dermatology Foundation, Member and Chair of the General Medicine A Study Section, Board of Scientific Counselors, National Cancer Institute, and National Advisory Council, National Institute for Arthritis and Musculoskeletal and Skin Diseases, all at National Institutes of Health. Dr Uitto is also section editor of the Journal of Investigative Dermatology and is on the editorial boards of numerous peer-reviewed journals.

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Publications

Most recent Peer-reviewed Publications

  1. Juxta-articular joint-capsule mineralization in CD73 deficient mice: Similarities to patients with NT5E mutations
  2. Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: Genotypic overlap with pseudoxanthoma elasticum
  3. Mouse models for pseudoxanthoma elasticum: Genetic and dietary modulation of the ectopic mineralization phenotypes
  4. Analysis of pseudoxanthoma elasticum-causing missense mutants of ABCC6 in vivo; Pharmacological correction of the mislocalized proteins
  5. Zebrafish as a model system to study skin biology and pathology
  6. Phenotypic Characterization of the KK/HlJ Inbred Mouse Strain
  7. Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts
  8. Clinical and histopathological characteristics of a family with R1141X mutation of pseudoxanthoma elasticum - presymptomatic testing and lack of carrier phenotypes
  9. Heritable disorders of connective tissue: Introduction to mini-review cluster
  10. Ectopic mineralization disorders of the extracellular matrix of connective tissue: Molecular genetics and pathomechanisms of aberrant calcification
  11. Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: The Abcc6 tm1Jfk and Enpp1 asj mutant mice
  12. Increased epidermal expression and absence of mutations in CARD14 in a series of patients with sporadic pityriasis rubra pilaris
  13. Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification
  14. Changes in dermal fibroblasts from Abcc6-/- mice are present before and after the onset of ectopic tissue mineralization
  15. Mouse alopecia areata and heart disease: Know your mouse!
  16. Pseudoxanthoma elasticum: Diagnostic features, classification and treatment options
  17. Genodermatoses: Differential diagnosis of cutaneous elastin disorders: Cutis Laxa vs. pseudoxanthoma elasticum
  18. Genodermatoses
  19. Rate of Change of Carotid Intima-Media Thickness with Magnesium Administration in Abcc6-/- Mice
  20. Premature termination codon read-through in the ABCC6 Gene: Potential treatment for pseudoxanthoma elasticum

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