David L Wiest, PhD

Contact Dr. Wiest

333 Cottman Avenue
Fox Chase Cancer Center 333
Philadelphia, PA 19111

(215) 728-2966
(215) 728-2412 fax

Research and Clinical Interests
T lymphocytes recognize and destroy invading pathogens through an assembly of proteins

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Publications

Most recent Peer-reviewed Publications

1. A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes
2. Control of hematopoietic stem cell emergence by antagonistic functions of ribosomal protein paralogs
3. Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B
4. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells
5. CD45-deficient severe combined immunodeficiency caused by uniparental disomy
6. Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling
7. Developmental arrest of T cells in Rpl22-deficient mice is dependent upon multiple p53 effectors
8. The Ras/MAPK pathway is required for generation of iNKT cells
9. Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization
10. Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development
11. Towards a molecular understanding of the differential signals regulating αβ/γδ T lineage choice
12. Origins of γδT cells: A forum for opposing perspectives
13. TCR-mediated ThPOK induction promotes development of mature (CD24-) γ δ thymocytes
14. Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells
15. Egr2 is required for Bcl-2 induction during positive selection
16. Marked Induction of the Helix-Loop-Helix Protein Id3 Promotes the γδ T Cell Fate and Renders Their Functional Maturation Notch Independent
17. Recurrent chromosomal rearrangements implicate oncogenes contributing to T-cell lymphomagenesis in Lck-MyrAkt2 transgenic mice
18. Identification of the Last cog in a ligand-independent signaling machine?
19. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death
20. Sustained expression of pre-TCR induced β-catenin in post-β-selection thymocytes blocks T cell development

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