Edward Winter, PhD

Contact Dr. Winter

233 South 10th Street
Suite 228
Philadelphia, PA 19107

(215) 503-4139
(215) 923-9162 fax

Research and Clinical Interests
Analysis of meiotic development using molecular genetics in yeast; signal transduction and protein kinases; transcriptional regulation.

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Publications

Most recent Peer-reviewed Publications

1. Activation of the smk1 mitogen-activated protein kinase by developmentally regulated autophosphorylation
2. The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae
3. The Cdk1 and Ime2 protein kinases trigger exit from meiotic prophase in Saccharomyces cerevisiae by inhibiting the Sum1 transcriptional repressor
4. The Ime2 protein kinase enhances the disassociation of the Sum1 repressor from middle meiotic promoters
5. The Ras/cAMP pathway and the CDK-like kinase Ime2 regulate the MAPK Smk1 and spore morphogenesis in Saccharomyces cerevisiae
6. Arg-Pro-X-Ser/Thr is a consensus phosphoacceptor sequence for the meiosis-specific Ime2 protein kinase in Saccharomyces cerevisiae
7. Phosphorylation of histone H4 Ser1 regulates sporulation in yeast and is conserved in fly and mouse spermatogenesis
8. Erratum: The Ama1-directed anaphase-promoting complex regulates the Smk1 mitogen-activated protein kinase during meiosis in yeast (Genetics (2005) 171, (901-911))
9. Phosphorylation of Ime2 regulates meiotic progression in Saccharomyces cerevisiae
10. Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts
11. The Ama1-directed anaphase-promoting complex regulates the Smk1 mitogen-activated protein kinase during meiosis in yeast
12. Recovery capacity of glial progenitors after in vivo fission-neutron or X irradiation: Age dependence, fractionation and low-dose-rate irradiations
13. RSC1 and RSC2 are required for expression of mid-late sporulation-specific genes in Saccharomyces cerevisiae
14. The Cdk-Activating Kinase Cak1p Promotes Meiotic S Phase through Ime2p
15. Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression
16. CAK1 promotes meiosis and spore formation in Saccharomyces cerevisiae in a CDC28-independent fashion
17. The pachytene checkpoint in Saccharomyces cerevisiae requires the Sum1 transcriptional repressor
18. Age dependence of the radiosensitivity of glial progenitors for in vivo fission-neutron and X irradiation
19. Sum1 and Hst1 repress middle sporulation-specific gene expression during mitosis in Saccharomyces cerevisiae
20. Distinct steps in yeast spore morphogenesis require distinct SMK1 MAP kinase thresholds

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