Graduate Program in Biochemistry & Molecular Pharmacology
Chemical & Structural Biology
Chemical & Structural Biology
|
Molecular & Cellular Pharmacology
|
Molecular Biology & Gene Regulation
Research in Chemical and Structural Biology at Jefferson aims to explore the function of biological systems at the molecular level, and to leverage the outcomes of that exploration for the development of novel disease treatments. Important molecular recognition events, such as receptor-ligand and protein-nucleic acid interactions, as well as the molecular mechanisms of catalysis, signal transduction and force generation, are probed using a broad range of biophysical tools, including x-ray crystallography, high-throughput screening, rapid kinetics and high-content imaging. Scientists training within this research emphasis develop a quantitative understanding of key cellular processes that contributes to our fundamental knowledge of human biology and disease.
| Areas of Research | Principle Investigators |
| Structural Biology | Benovic, Cingolani, Pascal, Root |
| Mechanisms Of Cell Growth And Differentiation | Benovic, Morrione, Rigoutsos, Wickstrom, Winter |
| Signal Integration/Cross-Talk | Benovic, Eto, Holinstat, Keen, Morrione, Winter |
| Protein Targeting & Trafficking | Benovic, Cingolani, Keen, Morrione, Root, Wedegaertner |
| Mechanisms Of Programmed Cell Death | Scott |
| Nucleic acid biochemistry and therapeutics | Hou, Kaji, Pascal, Morrione, Rigoutsos, Wickstrom, |
| Pharmacogenomics & Chemical Biology | Eto, Hickok, Quong, Rigoutsos, Scott |
| Cancer Biology | Kaji, Morrione, Quong, Scott Wickstrom, Zimmers |
| Cardiovascular Pharmacology | Eto, Holinstat, Sun |
| G-Protein Coupled Receptors | Benovic, Wedegaertner, |
| Tyrosine Kinase Receptors | Wickstrom |
| Imaging Technology | Forsberg, Keen, Wickstrom |
| Molecular Virology | Root |
