Graduate Program in Biochemistry & Molecular Pharmacology
Molecular & Cellular Pharmacology
Chemical & Structural Biology    |    Molecular & Cellular Pharmacology    |    Molecular Biology & Gene Regulation

ATPResearch in Molecular and Cellular Pharmacology at Jefferson broadly explores the mechanisms of cellular signal transduction pathways and their dysregulation in disease.  The interaction of ligands with their receptors and the resultant effects on cellular physiology are probed using state-of-the-art techniques in biochemistry, cell biology, imaging and model organisms.  The research focuses on a wide range of cellular signaling molecules, include G protein-coupled receptors, G proteins, receptor tyrosine kinases, intracellular kinases and phosphatases, nuclear hormone receptors, integrins, and proteins involved in apoptosis and membrane trafficking.  Discoveries from these laboratories are being actively translated into novel diagnostics and therapeutics in cancer pharmacology, neuropharmacology and cardiovascular pharmacology.

Areas of ResearchPrinciple Investigators
Mechanisms Of Cell Growth & Differentiation Aplin, Benovic, Languino, Nevalainen, Pestell, Pitari, Riobo, Rodeck, Rui, Sun, Waldman, Wedegaertner, Wickstrom, Winter
Signal Integration/Cross-Talk Alnemri, Aplin, Benovic, Brainard, Eto, Fortini, Hoek, Holinstat, Keen, Knudsen, Languino, Mahoney, Nevalainen, Pestell, Pitari, Riobo, Rodeck, Ronner, Rui, Sun, Uitto, Waldman, Wedegaertner, Winter
Protein Targeting & Trafficking Benovic, Cingolani, Fortini, Frank, Keen, Wedegaertner
Mechanisms Of Programmed Cell Death Alnemri, Dicker, Farber, Hoek, Pasinelli, Rodeck, Scott
Nucleic Acid Biochemistry & Therapeutics Brody, Dicker, Hou, Kaji, Mazo, Pascal, Wickstrom
Cancer Biology Aplin, Brody, Dicker, Farber, Frank, Kaji, Knudsen, Languino, Nevalainen, Pestell, Pitari, Quong, Rodeck, Rui, Scott, Waldman, Wickstrom, Zimmers
Metabolism & Mitochondrial Function Alnemri, Cingolani, Farber, Frank, Hoek, Holinstat, Hou, Ronner, Waldman, Zimmers
Neurodegenerative & Neuromuscular Diseases Chu, Dalva, Fortini, Hou, Iijima, Iijima-Ando, Merry, Pasinelli, Trotti
Genetic Regulation Of Development & Organogenesis Chu, Fortini, Hickok, Hoek, Mazo, Riobo, Winter, Mahoney, Uitto, Zimmers,
Structural Biology Benovic, Cingolani, Pascal
Cardiovascular Pharmacology Eto, Frank, Holinstat, Sun
G-Protein Coupled Receptors Benovic, Pestell, Riobo, Wedegaertner
Steroid Hormone Receptors Knudsen, Merry, Nevalainen, Rui
Tyrosine Kinase Receptors Rodeck, Rui, Wickstrom

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