Anni, Ph.D., Eleni 
Phone: (215) 955-5110
Email: eleni.anni@jefferson.edu

University of Patras, Greece, 1984. Biomarkers of alcoholism, anti-alcoholism drugs and proteomics.

Arafat, M.D., Ph.D., Hwyda 
Phone: (215) 955-6383
Email: HWYDA.ARAFAT@jefferson.edu

M.D., Ain Shams Medical School, Cairo, Egypt M.S., Ain Shams Medical School, Cairo, Egypt: Anatomy Ph.D., University of Medicine and Dentistry of New Jersey and Ain Shams Medical School: Cell Biology/Immunology. My laboratory is currently investigating the molecular mechanisms involved in the regulation of oxidative stress and inflammation signaling in two pancreatic diseases, type 1diabetes and pancreatic cancer.

Cahill, Ph.D., Alan 
Phone: (215) 955-0630
Email: Alan.Cahill@jefferson.edu

London, 1992. Mitochondrial dysfunction and alcoholic liver disease (ALD); relationship between ethanol-derived free radical production and hepatic mitochondrial DNA damage; protection by dietary supplements; role of aging in progression of ALD.

Covarrubias, M.D., Ph.D., Manuel L.
Phone: (215) 503-4341
Email: Manuel.Covarrubias@jefferson.edu

The structure, function and regulation of voltage-gated potassium channels

The long-term goal of our research is to gain mechanistic insights into the molecular basis of electrical signaling in neuronal and cardiac tissues. To reach this goal, we investigate two separate aspects: 1) the molecular physiology of somatodendritic potassium channels, and 2) the molecular architecture of a general anesthetic site in potassium channels.

Eisenman, Ph.D., Leonard M.
Phone: (215) 503-1686
Email: Leonard.Eisenman@jefferson.edu

Duke, 1974. Neuroscience: anatomical, developmental, and functional studies of the organization of the cerebellum with the use of rodents and neurologically mutant mice, with an emphasis on development of the topographic and synaptic organization of afferent systems to the cerebellum.

Ellingson, Ph.D., John S.
Phone: (215) 503-5021
Email: John.Ellingson@jefferson.edu

Michigan, 1967. To gain information relevant for correcting myelin-associated pathologies, e.g., multiple sclerosis or fetal alcohol syndrome, we are investigating the molecular and cellular regulation of myelin formation in differentiating oligodendrocytes, with an emphasis on identifying 1) the roles of protein kinase C (PKC) isozymes and 2) the ethanol-affected regulatory systems.

Enomoto-Iwamoto, Ph.D, D.D.S, Motomi 
Email: Motomi.Iwamoto@jefferson.edu

(Osaka University, Japan, 1987) Associate Professor, Department of Orthopaedic Surgery.
Research Interests: Wnt Signaling in chondrocytes during embryonic skeletogenesis and degradation.
Funding Support: National Institutes of Health (NIAMS).

Farber, M.D., John L.
Phone: (215) 503-5066
Email: John.Farber@jefferson.edu

Professor; M.D., University of California (San Francisco), 1966. Biochemical mechanisms of cell injury in ischemia of liver cell necrosis; biochemical toxicology of activated oxygen; chemical carcinogenesis.

Fenderson, Ph.D., Bruce A.
Phone: 215-503-2256
Email: Bruce.Fenderson@jefferson.edu

Johns Hopkins, 1980. Mechanisms of morphogenesis and malignancy; role of cell-surface carbohydrates in mediation of cell recognition during development; use of monoclonal anticarbohydrate antibodies to study lineage formation, cell differentiation, and neoplastic transformation.

Fertala, Ph.D., Andrzej 
Phone: (856) 770-1671
Email: Andrzej.Fertala@jefferson.edu

(University of Silesia, Poland, 1982), Associate Professor, Department of Dermatology and Cutaneous Medicine
Research Interests: Mechanism of self assembly of fibrillar collagen; use of "smart collagen" for tissue engineering; skeletal regeneration.
Funding Support: National Institute of Health (NIAMS, NASA).

Force, M.D., Thomas L
Phone: 215-503-9520
Email: thomas.force@jefferson.edu

My lab focuses on the regulation of normal and stress-induced cardiomyocyte hypertrophy. Specifically, we study the signal transduction pathways that regulate growth responses, focusing on protein kinase cascades. Most recently, we have studied the role of glycogen synthase kinase-3beta, which is a potent negative regulator of growth, and its downstream targets, which include beta-catenin and its co-factors, the Tcf family of transcription factors, and the family of nuclear factors of activated T cells (NF-ATs), in hypertrophic growth. In addition, we study signaling mechanisms that regulate the response of the cell to ischemic injury. Making use of novel small molecule inhibitors, we have recently identifyied a novel mechanism by which the JNK family of stress-activated protein kinases regulate activity of the pro-survival kinase, Akt/PKB, and, via this mechanism, cardiomyocyte survival following ischemia/reperfusion.

Freeman, PHD, Theresa  A.
Phone: 215-955-1068
Email: theresa.freeman@jefferson.edu

Gonye, Ph.D., Gregory E.
Phone: (215) 955-0580
Email: ggonye@mail.dbi.tju.edu

Connecticut, 1993. Molecular neuroscience: role of transcriptional regulation in neuromodulation, concentrating on nucleus tractus solitarius neurons, neuropeptides (angiotensin II), and RGS proteins; effects of ethanol on neuromodulation; development of computational approaches to study neuromodulation, including modeling and simulation and bioinformatic tools.

Gorstein, M.D., Fred 
Phone: 215-955-5060
Email: Fred.Gorstein@jefferson.edu

NYU, 1955.

Department Chair
279 Jefferson Alumni Hall
1020 Locust Street
Philadelphia, PA
19107
Phone: 215-955-5060

Grunwald, Ph.D., Gerald B.
Phone: (215) 503-4191
Email: Gerald.Grunwald@jefferson.edu

Professor; Ph.D., Wisconsin, 1981. Developmental biology and neuroscience; eye development and disease, analysis of the role of cadherin cell adhesion molecules in normal and abnormal embryonic development and in proliferative diseases of the nervous mechanisms of cadherin expression and function.

Hajnoczky, Ph.D., Gyorgy 
Phone: (215) 503-1427
Email: Gyorgy.Hajnoczky@jefferson.edu

Semmelweis, Budapest, 1987; Ph.D., National Academy of Sciences, Hungary, 1995. Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Hoek, Ph.D., Jan B.
Phone: (215) 503-5016
Email: Jan.Hoek@jefferson.edu

Amsterdam, 1972. Systems biology of intracellular signal transduction networks; deregulation of cytokine and growth factor signaling in the liver associated with chronic alcohol consumption; early signaling responses during liver regeneration; bioenergetics and mitochondrial metabolism and its role in intracellular signaling and apoptosis.

Horn, Ph.D., Richard 
Phone: 215-503-6725
Email: Richard.Horn@jefferson.edu

California, Los Angeles, 1977. Molecular physiology of ion channels. The long-term objective of my laboratory is to elucidate the molecular correlates of the biophysical properties of voltage-dependent ion channels, using a combination of patch recording, molecular biology, cysteine scanning mutagenesis, and immobilization of the moving parts of the channels (voltage sensors and gates) by photocross-linking. We use both sodium and potassium channels in these studies.

Iacovitti, Ph.D., Lorraine 
Phone: (215) 955-8118
Email: Lorraine.Iacovitti@jefferson.edu

Cornell, 1979. Developmental biology and neuroscience; mechanisms of neuronal cell differentiation and development of neurotransmitter class; application of immortalized stem cells to treat neurodegenerative diseases such as Parkinson's and Alzheimer's.

Iozzo, M.D., Ph.D., Renato V.
Phone: (215) 503-2208
Email: Renato.Iozzo@jefferson.edu

Florence, 1975. Biosynthesis, structure, and metabolism of proteoglycans in normal and malignant cells; analysis of the cell-surface heparin sulfate proteoglycan synthesized by human colon carcinoma cells, and the regulation of molecular assembly, posttranslational modifications, and turnover of this class of macromolecules; interactions between malignant epithelial cells and normal mesenchymal cells in vitro and the effects on extracellular matrix gene expression.

Iwamoto, D.D.S., Ph.D, Masahiro 
Phone: 215-955-4076
Email: Masahiro.Iwamoto@jefferson.edu

(Osaka University, Japan, 1988) Associate Professor, Department of Orthopaedic Surgery.
Research Interests: Determining the mechanism of specification of the phenotype of articular chondrocytes.
Funding Support: Yamanouchi USA Foundation.

Jaynes, Ph.D., James B.
Phone: 215-503-4778
Email: jaynes@jci.tju.edu

Ph.D., University of Washington, Seattle, WA 1980. Developmental genetics and molecular biology of processes regulated by homeodomain transcription factors and higher order chromatin structure.

Joseph, Ph.D., Suresh K.
Phone: (215) 503-1221
Email: Suresh.Joseph@jefferson.edu

Bristol (England). Structure, function, and regulation of the inositol trisphosphate receptor (IP3R); biosynthesis and assembly of IP3R homo- and heteroligomers; mechanisms of proteosomal and lysosomal degradation of IP3R.

Kaji, Ph.D., Hideko 
Phone: 215-503-6547
Email: Hideko.Kaji@jefferson.edu

Ph.D., Purdue, 1958. Molecular mechanisms/function of Ribosome Recycling Factor (RRF) in protein synthesis; Biochemical pharmacology of human anti-retroviral drugs.

Kholodenko, Ph.D., Boris N.
Phone: (215) 503-1614
Email: Boris.Kholodenko@jefferson.edu

Moscow, 1976. Systems biology; quantitative analysis of spatio-temporal dynamics of cellular signaling and gene networks through biochemical, molecular biological, genetic, and computational cell biology methods.

Lisanti, M.D., Ph.D., Michael Phillip
Phone: 215-503-9295
Email: michael.lisanti@kimmelcancercenter.org

B.A., New York University, Chemistry, 1985 Ph.D., Cornell University Medical College, Cell Biology and Genetics, 1991 M.D., Cornell University Medical College, Medicine, 1992 Visiting Scientist, Rockefeller University, NY, 1991-1992 Fellow, Whitehead Institute/Massachusetts Institute of Technology (MIT), Cambridge, MA, 1992-1997 The focus of my laboratory is to understand, at the molecular and cellular level, the role of caveolin-1 (Cav-1) in i) normal signaling and ii) pathogenic signaling during the development of human cancers. Our work over the last decade directly demonstrates that Cav-1 functions as a brake during signal transduction, akin to the behavior of other tumor suppressor genes.

Mazo, Ph.D., Alexander M.
Phone: 215-503-4785
Email: Mazo@mail.tju.edu

Ph.D., Institute of Molecular Biology, Moscow, Russia, 1976. Transcriptional regulation by epigenetic factors and nuclear hormone receptors.

McMahon, Ph.D., Steven 
Phone: 215-503-9064
Email: Steven.McMahon@jci.tju.edu

Dr. McMahon has identified 40 novel MYC targets, which include MTAI, BAG-1,POLRT and CD30, and current investigations seek to explore their biological significance during MYC-mediated transformation. Dr. McMahons lab is also focused on examining the regulation of p53 function by acetylation at lysine K120; Interested in exploring multiple aspects surrounding the ubiquitin hydrolase USP22.

Menko, Ph.D., A. Sue
Phone: (215) 503-2166
Email: sue.menko@jefferson.edu

Pennsylvania, 1978. Role of integrins in the regulation of cell differentiation: Integrin signalling of cell differentiation events, particularly integrin-growth factor receptor coordinated signalling.

Merry, Ph.D., Diane E.
Phone: (215) 503-4907
Email: Diane.Merry@jefferson.edu

The research in my lab centers on understanding the molecular pathways by which motor neurons become dysfunctional in response to expression of polyglutamine-expanded androgen receptor in the neurodegenerative disease spinal and bulbar muscular atrophy. In a more general sense, these studies are designed to understand how neurons respond to the accumulation of misfolded proteins. Thus, much of the research in my lab is disease-driven basic research.

Pacifici, Ph.D., Maurizio 
Phone: 215-955-7352
Email: Maurizio.Pacifici@jefferson.edu

(University of Rome, 1974) Professor, Department of Orthopaedic Surgery, Associate Director, Division of Orthopaedic Research.
Research Interests: Role and mechanisms of action of signaling factors in skeletogensis; joint development.
Funding Support: National Institute of Health (NIAMS).

Paumet, Fabienne 
Phone: 215-503-8567
Email: Fabienne.Paumet@jefferson.edu

Philp, Ph.D., Nancy J.
Phone: 215-503-7854
Email: Nancy.Philp@jefferson.edu

Ponnappa, Ph.D., Biddanda C.
Phone: (215) 503-5018
Email: biddanda.ponnappa@jefferson.edu

Current research interests include a) development of liposome-mediated drug delivery system to target macrophages in vivo in animal model systems, b) construction of antisense oligonucleotides and siRNAs against inflammatory cytokines of macrophagic origin and c) to explore the therapeutic potential of curcumin, an herbal product, in the treatment of cancer and alcoholic liver disease.

Radice, Ph.D., Glenn 
Email: Glenn.Radice@jefferson.edu

Abnormal tissue architecture is associated with many forms of disease including cardiomyopathy and cancer. The Radice lab investigates the function of cadherins, a family of cell adhesion molecules, responsible for maintaining cell-cell interactions and communication under normal and pathological conditions. Gene targeted mouse models are used to understand the relationship between adherens junctions and gap junctions and how malfunction of these junctional complexes leads to sudden arrhythmic death.

Rubin, M.D., Raphael 
Phone: 215-955-5031
Email: Raphael.Rubin@jefferson.edu

B.A., Boston University, 6-year Medical Program, 1979 M.D., Boston University School of Medicine, 1979 Surgical Pathology Gastrointestinal/Liver pathology Growth factor and tyrosine kinase signaling Insulin-like growth factor receptor signaling Effects of alcohol on cell signaling.

Rubin, M.D., Emanuel 
Phone: (215) 955-5060
Email: Emanuel.Rubin@jefferson.edu

B.S., Villanova University, 1950 M.D., Harvard Medical School, 1954

Rui, M.D., Ph.D., Hallgeir 
Phone: 215-503-9259
Email: Hallgeir.Rui@jefferson.edu

The Laboratory''s current research is focused on mechanistic identification of aberrant Jak-Stat signal transduction during human breast cancer progression that the laboratory has discovered. Recent progress includes recognition of the prolactin-induced Jak2-Stat5 pathway as a pro-differentiation pathway in human breast cancer, which during progression of human breast cancer is replaced by aberrant signaling through a Jak1-Stat3 pathway that may promote invasion and metastasis. Consistent with this notion, new data demonstrate that activation of Stat5 is a highly favorable prognostic marker in node-negative breast cancer. An invasion-suppressive role of Stat5 in human breast cancer may explain the mechanism of the favorable prognosis associated with active Stat5 in early stage breast cancer. A new technology for microarraying of tissue, cells, and other solid materials, cutting edge matrix assembly (CEMA), has been developed.

San Antonio, Ph.D., James D.
Phone: (215) 955-6121
Email: James.SanAntonio@jefferson.edu

(University of Pennsylvania, 1987) Associate Professor, Department of Medicine and the Cardeza Foundation for Hematologic Research.
Research Interests: mechanisms of angiogenesis and chondrogenesis; vascular smooth muscle cell growth and differentiation; atherosclerosis and restenosis; biochemistry and functions of proteoglycan-collagen interactions; tissue engineering; development of autologous organ implants.
Funding Support: National Institutes of Health (NHLB); American Heart Foundation; Private Foundations.

Schneider, Ph.D., Jay S.
Phone: (215) 503-0370
Email: Jay.Schneider@jefferson.edu

Schwaber, Ph.D., James S
Email: James.Schwaber@jefferson.edu

Srinivas, Ph.D., Vickram 
Phone: 215-955-7372
Email: Vickram.Srinivas@jefferson.edu

Strayer, M.D., Ph.D., David S.
Phone: (215) 503-1087
Email: David.Strayer@jefferson.edu

M.D., University of Chicago Ph.D., University of Chicago.

Taraschi, Ph.D., Theodore F.
Phone: (215) 503-5020
Email: Theodore.Taraschi@jefferson.edu

Ph.D., Rutgers University, Chemistry, 1980. Vice Chair for Education, Department of Pathology, Anatomy & Cell Biology. Program Director, Cell & Developmental Biology Program

Areas of research include:
1) Elucidation of parasite protein trafficking pathways from intracellular parasites to the erythrocyte cytosol and host cell membrane.
2) Determinantion of the mechanism of hemoglobin uptake and transport by intraerythrocytic parasites.
3) Characterization of parasite DNA repair pathways (e.g. base excision and mismatch repair). Continued identification of the cellular components of these trafficking pathways to gain a better understanding of transport mechanisms in malaria-infected erythrocytes.

Uitto, M.D., Ph.D., Jouni J.
Phone: (215) 503-5785
Email: Jouni.Uitto@jefferson.edu

(University of Helsinki, 1970) Professor and Chair, Department of Dermatology and Cutaneous Biology; Professor of Biochemistry and Molecular Pharmacology; Director, Jefferson Institute of Molecular Medicine.
Research Interests: Molecular biology of the cutaneous basement membranes; genetic disorders of the skin; heritable connective tissue disorders.
Funding Support: National Institutes of Health (NIAMS); Dermatology Foundation.

Van Bockstaele, Ph.D., Elisabeth J.
Phone: 215-503-1245

B.A., Sarah Lawrence College, Biology, 1985 M.S., New York University, Neurobiology, 1988 Ph.D., New York University, Neurobiology, 1991 Dr. Van Bockstaele is an active faculty member in the education of medical students and residents at TJU. She coordinates basic science research activities focused in the neurosciences and assists residents in developing research projects during their research rotations. As a mentor for numerous graduate and medical students over the past ten years, Dr. Van Bockstaele has demonstrated expertise in training postgraduate students. Her participation on NIH study sections aimed at supporting research programs for PhD, MD and MD/PhD applicants will facilitate the submission of such proposals from current neuroscience graduate students and neurosurgical residents.

Waldman, M.D., Ph.D., Scott A.
Phone: (215) 955-6086
Email: Scott.Waldman@jefferson.edu

Professor; Ph.D., Thomas Jefferson, 1980; M.D., Stanford, 1987. Molecular mechanisms of signal transduction, with emphasis on receptor-effector coupling and post-receptor signaling mechanisms; molecular mechanisms underlying tissue-specific transcriptional regulation; translation of molecular signaling mechanisms to novel diagnostic and therapeutic approaches to patients with cancer.

Wedegaertner, Ph.D., Philip B.
Phone: 215-503-3137
Email: Philip.Wedegaertner@mail.jci.tju.edu

Ph.D., University of California, San Diego, CA. 1991. G-protein signal transduction; molecular mechanisms and functions of covalent modifications and regulated subcellular localization.

Winter, Ph.D., Edward 
Phone: (215) 503-4139
Email: Edward.Winter@jefferson.edu

Ph.D., SUNY at Stony Brook, 1984. Meiotic development; chromosome structure and function; MAP kinase signaling pathways in yeast.