Anni, Ph.D., Eleni 
Phone: 215-503-5064
Email: eleni.anni@jefferson.edu

University of Patras, Greece, 1984. Biomarkers of alcoholism, anti-alcoholism drugs and proteomics.

Arafat, M.D., Ph.D., Hwyda 
Phone: (215) 955-6383
Email: HWYDA.ARAFAT@jefferson.edu

M.D., Ain Shams Medical School, Cairo, Egypt M.S., Ain Shams Medical School, Cairo, Egypt: Anatomy Ph.D., University of Medicine and Dentistry of New Jersey and Ain Shams Medical School: Cell Biology/Immunology. My laboratory is currently investigating the molecular mechanisms involved in the regulation of oxidative stress and inflammation signaling in two pancreatic diseases, type 1diabetes and pancreatic cancer.

Cahill, Ph.D., Alan 
Phone: (215) 955-0630
Email: Alan.Cahill@jefferson.edu

London, 1992. Mitochondrial dysfunction and alcoholic liver disease (ALD); relationship between ethanol-derived free radical production and hepatic mitochondrial DNA damage; protection by dietary supplements; role of aging in progression of ALD.

Covarrubias, M.D., Ph.D., Manuel L.
Phone: (215) 503-4341
Email: Manuel.Covarrubias@jefferson.edu

The structure, function and regulation of voltage-gated potassium channels

The long-term goal of our research is to gain mechanistic insights into the molecular basis of electrical signaling in neuronal and cardiac tissues. To reach this goal, we investigate two separate aspects: 1) the molecular physiology of somatodendritic potassium channels, and 2) the molecular architecture of a general anesthetic site in potassium channels.

Eisenman, Ph.D., Leonard M.
Phone: (215) 503-1686
Email: Leonard.Eisenman@jefferson.edu

Duke, 1974. Neuroscience: anatomical, developmental, and functional studies of the organization of the cerebellum with the use of rodents and neurologically mutant mice, with an emphasis on development of the topographic and synaptic organization of afferent systems to the cerebellum.

Enomoto-Iwamoto, Ph.D, D.D.S, Motomi 
Email: Motomi.Iwamoto@jefferson.edu

(Osaka University, Japan, 1987) Associate Professor, Department of Orthopaedic Surgery.
Research Interests: Wnt Signaling in chondrocytes during embryonic skeletogenesis and degradation.
Funding Support: National Institutes of Health (NIAMS).

Fenderson, Ph.D., Bruce A.
Phone: 215-503-2256
Email: Bruce.Fenderson@jefferson.edu

Johns Hopkins, 1980. Mechanisms of morphogenesis and malignancy; role of cell-surface carbohydrates in mediation of cell recognition during development; use of monoclonal anticarbohydrate antibodies to study lineage formation, cell differentiation, and neoplastic transformation.

Fertala, Ph.D., Andrzej 
Phone: 215-503-0113
Email: Andrzej.Fertala@jefferson.edu

(University of Silesia, Poland, 1982), Associate Professor, Department of Dermatology and Cutaneous Medicine
Research Interests: Mechanism of self assembly of fibrillar collagen; use of "smart collagen" for tissue engineering; skeletal regeneration.
Funding Support: National Institute of Health (NIAMS, NASA).

Force, M.D., Thomas L
Phone: 215-503-9520
Email: thomas.force@jefferson.edu

My lab focuses on the regulation of normal and stress-induced cardiomyocyte hypertrophy. Specifically, we study the signal transduction pathways that regulate growth responses, focusing on protein kinase cascades. Most recently, we have studied the role of glycogen synthase kinase-3beta, which is a potent negative regulator of growth, and its downstream targets, which include beta-catenin and its co-factors, the Tcf family of transcription factors, and the family of nuclear factors of activated T cells (NF-ATs), in hypertrophic growth. In addition, we study signaling mechanisms that regulate the response of the cell to ischemic injury. Making use of novel small molecule inhibitors, we have recently identifyied a novel mechanism by which the JNK family of stress-activated protein kinases regulate activity of the pro-survival kinase, Akt/PKB, and, via this mechanism, cardiomyocyte survival following ischemia/reperfusion.

Freeman, PHD, Theresa  A.
Phone: 215-955-1068
Email: theresa.freeman@jefferson.edu

Initiating pathology of osteoarthritis; early factors involving vascular invasion of articular cartilage and subchondral bone remodeling in osteoarthritic progression. Molecular mechanisms of Arthrofibrosis, an aberrant fibrotic response to total knee replacement surgery.

Gonye, Ph.D., Gregory E.
Phone: (215) 955-0580
Email: ggonye@mail.dbi.tju.edu

Connecticut, 1993. Molecular neuroscience: role of transcriptional regulation in neuromodulation, concentrating on nucleus tractus solitarius neurons, neuropeptides (angiotensin II), and RGS proteins; effects of ethanol on neuromodulation; development of computational approaches to study neuromodulation, including modeling and simulation and bioinformatic tools.

Grunwald, Ph.D., Gerald B.
Phone: (215) 503-4191
Email: Gerald.Grunwald@jefferson.edu

Professor; Ph.D., Wisconsin, 1981. Developmental biology and neuroscience; eye development and disease, analysis of the role of cadherin cell adhesion molecules in normal and abnormal embryonic development and in proliferative diseases of the nervous mechanisms of cadherin expression and function.

Hajnoczky, M.D., Ph.D., Gyorgy 
Phone: (215) 503-1427
Email: Gyorgy.Hajnoczky@jefferson.edu

Semmelweis, Budapest, 1987; Ph.D., National Academy of Sciences, Hungary, 1995. Intracellular calcium signaling; inositol trisphosphate-linked hormones; organization of calcium mobilization from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signaling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Hoek, Ph.D., Jan B.
Phone: (215) 503-5016
Email: Jan.Hoek@jefferson.edu

Amsterdam, 1972. Systems biology of intracellular signal transduction networks; deregulation of cytokine and growth factor signaling in the liver associated with chronic alcohol consumption; early signaling responses during liver regeneration; bioenergetics and mitochondrial metabolism and its role in intracellular signaling and apoptosis.

Iacovitti, Ph.D., Lorraine 
Phone: (215) 955-8118
Email: Lorraine.Iacovitti@jefferson.edu

Cornell, 1979. Developmental biology and neuroscience; mechanisms of neuronal cell differentiation and development of neurotransmitter class; application of immortalized stem cells to treat neurodegenerative diseases such as Parkinson's and Alzheimer's.

Iozzo, M.D., Renato V.
Phone: 215-503-2208
Email: Iozzo@mail.jci.tju.edu

Professor of Pathology and Cell Biology, and Director of the Extracellular Matrix Program at the Kimmel Cancer Center, Thomas Jefferson University. After receiving an M.D. degree summa cum laude from the University of Florence, Italy, he moved to the Department of Pathology at the University of Washington, where he completed a five-year Residency/Fellowship. Following a six-year faculty appointment at the University of Pennsylvania, he moved to Thomas Jefferson University. Dr. Iozzo has received many awards including the Benjamin Castleman Award from the International Academy of Pathology, the Junior Faculty Research Award from the American Cancer Society, the Burlington Resources Foundation Faculty Achievement Award, and the Faculty Research Award from the American Cancer Society. In 2008, Dr. Iozzo received an Honorary Professorship at the School of Life Sciences, University of Manchester, UK. His research focuses on the biology of proteoglycans and their roles in cancer and angiogenesis.

Iwamoto, D.D.S., Ph.D, Masahiro 
Phone: 215-955-4076
Email: Masahiro.Iwamoto@jefferson.edu

(Osaka University, Japan, 1988) Associate Professor, Department of Orthopaedic Surgery.
Research Interests: Determining the mechanism of specification of the phenotype of articular chondrocytes.
Funding Support: Yamanouchi USA Foundation.

Jaynes, Ph.D., James B.
Phone: 215-503-4778
Email: jaynes@jci.tju.edu

Ph.D., University of Washington, Seattle, WA 1980. Developmental genetics and molecular biology of processes regulated by homeodomain transcription factors and higher order chromatin structure.

Joseph, Ph.D., Suresh K.
Phone: (215) 503-1221
Email: Suresh.Joseph@jefferson.edu

Bristol (England). Structure, function, and regulation of the inositol trisphosphate receptor (IP3R); biosynthesis and assembly of IP3R homo- and heteroligomers; mechanisms of proteosomal and lysosomal degradation of IP3R.

Kaji, Ph.D., Hideko 
Phone: 215-503-6547
Email: Hideko.Kaji@jefferson.edu

Ph.D., Purdue, Molecular mechanisms/function of A) prokaryotic and eukaryotic ribosome recycling in protein synthesis B) protein modification by arginylation via arginyl tRNA protein transferase.

Knudsen, Ph.D., Erik 
Phone: 215-503-8578
Email: Erik.Knudsen@jefferson.edu

RB Tumor Suppressor Pathway Involvement in Cancer Etiology and Therapeutic Response
Research Foci: Research is focused on the retinoblastoma tumor suppressor (RB). This tumor suppressor is lost or functionally inactivated in the majority of human cancers. The Knudsen laboratory takes a multi-disciplinary approach to understanding how RB functions to inhibit tumorigenesis and to devise new means to effectively target the RB-pathway in the treatment of cancer.

Koch, Ph.D., Walter J
Phone: (215) 955-9982
Email: Walter.Koch@jefferson.edu

The Koch laboratory currently is investigating molecular mechanisms involved in the regulation of signaling through cardiovascular adrenergic receptors (ARs) and the role this plays in heart disease, primarily heart failure (HF). The labs research primarily targets a family of kinases known to regulate ARs and other G protein-coupled receptors (GPCRs) known as the GPCR kinases (GRKs). These GRKs appear to be critically involved in normal and failing heart function and we are manipulating the expression and activity of GRKs in the cardiovascular system.

Lisanti, M.D., Ph.D., Michael Phillip
Phone: 215-503-9295
Email: michael.lisanti@kimmelcancercenter.org

B.A., New York University, Chemistry, 1985 Ph.D., Cornell University Medical College, Cell Biology and Genetics, 1991 M.D., Cornell University Medical College, Medicine, 1992 Visiting Scientist, Rockefeller University, NY, 1991-1992 Fellow, Whitehead Institute/Massachusetts Institute of Technology (MIT), Cambridge, MA, 1992-1997 The focus of my laboratory is to understand, at the molecular and cellular level, the role of caveolin-1 (Cav-1) in i) normal signaling and ii) pathogenic signaling during the development of human cancers. Our work over the last decade directly demonstrates that Cav-1 functions as a brake during signal transduction, akin to the behavior of other tumor suppressor genes.

Mazo, Ph.D., Alexander M.
Phone: 215-503-4785
Email: Mazo@mail.tju.edu

Ph.D., Institute of Molecular Biology, Moscow, Russia, 1976. Transcriptional regulation by epigenetic factors and nuclear hormone receptors.

McMahon, Ph.D., Steven 
Phone: 215-503-9064
Email: Steven.McMahon@jci.tju.edu

Dr. McMahon has identified 40 novel MYC targets, which include MTAI, BAG-1,POLRT and CD30, and current investigations seek to explore their biological significance during MYC-mediated transformation. Dr. McMahons lab is also focused on examining the regulation of p53 function by acetylation at lysine K120; Interested in exploring multiple aspects surrounding the ubiquitin hydrolase USP22.

Menko, Ph.D., A. Sue
Phone: (215) 503-2166
Email: sue.menko@jefferson.edu

Pennsylvania, 1978. Role of integrins in the regulation of cell differentiation: Integrin signalling of cell differentiation events, particularly integrin-growth factor receptor coordinated signalling.

Merry, Ph.D., Diane E.
Phone: (215) 503-4907
Email: Diane.Merry@jefferson.edu

The research in my lab centers on understanding the molecular pathways by which motor neurons become dysfunctional in response to expression of polyglutamine-expanded androgen receptor in the neurodegenerative disease spinal and bulbar muscular atrophy. In a more general sense, these studies are designed to understand how neurons respond to the accumulation of misfolded proteins. Thus, much of the research in my lab is disease-driven basic research.

Pacifici, Ph.D., Maurizio 
Phone: 215-955-7352
Email: Maurizio.Pacifici@jefferson.edu

University of Rome, 1974 Professor, Department of Orthopaedic Surgery; Director, Division of Orthopaedic Research

Dr. Pacifici's biomedical research work focuses on mechanisms controlling skeletal development and growth in fetal and postnatal life. Emphasis is on identification of molecular regulators acting at the nuclear level that direct commitment, determination and differentiation of progenitor skeletal cells. Overall goal is to target those regulators in gene- and drug-based therapies to repair and reconstruct skeletal tissues affected by pathologies, including osteoarthritis and congenital skeletal defects.

Paumet, Fabienne 
Phone: 215-503-8567
Email: Fabienne.Paumet@jefferson.edu

MOLECULAR MECHANISMS OF PHAGOCYTOSIS: how do pathogens subvert this process? *Unraveling membrane trafficking involved in the phagocytic pathway and its regulation *How do bacteria interfere with the host phagocytic system to escape lysosomal degradation?
CHARACTERIZATION OF EUKARYOTIC MEMBRANE FUSION MACHINERY
*Identification and characterization of primitive membrane fusion machineries (similar to SNARE proteins?)
*Characterization of the specificity of fusion encoded in the SNARE proteins
*Characterization of intramolecular SNARE regulation

Pestell, M.D., Ph.D., Richard G
Phone: 215-503-5692
Email: Cecilia.Deemer@kimmelcancercenter.org

Professor of Oncology and Medicine
Director, Kimmel Cancer Center

Dr. Pestell completed his M.D. (1981) and Ph.D. degrees in Australia. He undertook post doctoral and clinical training in Hematology/Oncology and Endocrinology and continued research at Harvard University and served as Clinical fellow at Massachusetts General Hospital.

Major contributions are to the area of cell-cycle control and targeted cancer therapies. These include the discovery that cyclins are direct transcriptional targets of oncogenic and tumor suppressor signals and that cyclin expression is rate-limiting for oncogene-induced tumor growth in vivo. His laboratory pioneered the application of tissue-specific inducible transgenics and the development of gene-targeted and transgenic mice providing superior model of human cancer. His patent of light activated gene therapy, which allows single cell targeting of a payload, is broad including all genes in the human genome.

Philp, Ph.D., Nancy J.
Phone: 215-503-7854
Email: Nancy.Philp@jefferson.edu

Research interest is a combianation of monocarboxylate transporters; CD147; retinal pigmment epithelium; retinal metabolism; glycolysis, and JAM-C

Ponnappa, Ph.D., Biddanda C.
Phone: (215) 503-5018
Email: biddanda.ponnappa@jefferson.edu

Current research interests include a) development of liposome-mediated drug delivery system to target macrophages in vivo in animal model systems, b) construction of antisense oligonucleotides and siRNAs against inflammatory cytokines of macrophagic origin and c) to explore the therapeutic potential of curcumin, an herbal product, in the treatment of cancer and alcoholic liver disease.

Radice, Ph.D., Glenn 
Phone: 215-503-5157
Email: Glenn.Radice@jefferson.edu

Abnormal tissue architecture is associated with many forms of disease including cardiomyopathy and cancer. The Radice lab investigates the function of cadherins, a family of cell adhesion molecules, responsible for maintaining cell-cell interactions and communication under normal and pathological conditions. Gene targeted mouse models are used to understand the relationship between adherens junctions and gap junctions and how malfunction of these junctional complexes leads to sudden arrhythmic death.

Rostami, Abdolmohamad 
Phone: 215-955-1234
Email: A.M.Rostami@jefferson.edu

My research focuses on...

1) The role of IL-12/IL-17/IL-23 axis in the pathogenesis of EAE and multiple sclerosis.

2) The effect of the Bowman-Birk protease inhibitor on the course of EAE. This study has the potential to provide a novel, safe, and effective therapy for multiple sclerosis.

3) Mechanisms of intravenous tolerance in EAE.

Rubin, M.D., Emanuel 
Phone: 215-503-5733
Email: Emanuel.Rubin@jefferson.edu

B.S., Villanova University, 1950 M.D., Harvard Medical School, 1954

Rubin, M.D., Raphael 
Phone: 215-955-5031
Email: Raphael.Rubin@jefferson.edu

B.A., Boston University, 6-year Medical Program, 1979 M.D., Boston University School of Medicine, 1979 Surgical Pathology Gastrointestinal/Liver pathology Growth factor and tyrosine kinase signaling Insulin-like growth factor receptor signaling Effects of alcohol on cell signaling.

Rui, M.D., Ph.D., Hallgeir 
Phone: 215-503-9259
Email: Hallgeir.Rui@jefferson.edu

The Laboratory''s current research is focused on mechanistic identification of aberrant Jak-Stat signal transduction during human breast cancer progression that the laboratory has discovered. Recent progress includes recognition of the prolactin-induced Jak2-Stat5 pathway as a pro-differentiation pathway in human breast cancer, which during progression of human breast cancer is replaced by aberrant signaling through a Jak1-Stat3 pathway that may promote invasion and metastasis. Consistent with this notion, new data demonstrate that activation of Stat5 is a highly favorable prognostic marker in node-negative breast cancer. An invasion-suppressive role of Stat5 in human breast cancer may explain the mechanism of the favorable prognosis associated with active Stat5 in early stage breast cancer. A new technology for microarraying of tissue, cells, and other solid materials, cutting edge matrix assembly (CEMA), has been developed.

Schneider, Ph.D., Jay S.
Phone: (215) 503-0370
Email: Jay.Schneider@jefferson.edu

Focus: Basic, clinical and translational research on on cognitive and motor aspects of Parkinson's disease with focuses on both symptomatic and neuroprotective treatment strategies; basic and clinical research on developmental neurotoxicology with an emphasis on lead-induced damage to the brain.

Schwaber, Ph.D., James S.
Phone: 215-503-7823
Email: James.Schwaber@jefferson.edu

Director of Daniel Baugh Institute for Functional Genomics and Computational Biology; Department of Pathology, Anatomy & Cell Biology
Adjunct Professor Chemical Engineering, University of Delaware

Dr. Schwaber uses systems biology approaches in mammalian brain to study adaptive neuronal processes. Specifically his interests involve mechanisms by which hypertension arises in homeostatic cardiorespiratory regulatory circuits, by which the symptoms of alcohol withdrawal are produced and by which phase shifting of light causes the brain''s master clock to reorganize circadian behavior.

Srinivas, Ph.D., Vickram 
Phone: 215-955-7372
Email: Vickram.Srinivas@jefferson.edu

PhD, University of Maryland, Baltimore

Current investigations of this laboratory are aimed at bringing together new ideas concerning chondrocyte metabolism, the impact of the local environment and the mechanism of cell death. The central focus is on the regulation of the autophagic flux. We have found that chondrocyte autophagy is monitored by the activities of three environmental sensors: the oxygen sensors HIF-1 and HIF-2, the energy sensor AMPK, and growth factor and nutritional sensor mTOR. We have also extended this area of investigation to determine the role of the above mentioned factors and activities in the onset and pathogenesis of cartilage pathologies such as osteoarthritis. In addition, a new area of investigation that we have very recently begun investigating, is the role of microRNAs in chondrocyte biology and chondrocyte autophagy.

Strayer, M.D., Ph.D., David S.
Phone: (215) 503-1087
Email: David.Strayer@jefferson.edu

Aids; Bioterrorism; Botulinum Toxin; Cell Biology; Cell Growth Regulation; Complementary Dna; Dna Footprinting; Gene Expression; Gene Induction Repression; Gene Therapy; Genetic Promoter Element; Genetics; Molecular Cloning; Nucleic Acid Sequence; Poxviruses; Site Directed Mutagenesis; Sv40; Tissue Cell Culture; Transcription Factor; Transfection; Tumor Suppressor Gene; Viral Genetics; Virology

Taraschi, Ph.D., Theodore F.
Phone: (215) 503-5020
Email: Theodore.Taraschi@jefferson.edu

Ph.D., Rutgers University, Chemistry, 1980. Vice Chair for Education, Department of Pathology, Anatomy & Cell Biology. Program Director, Cell & Developmental Biology Program

Areas of research include:
1) Elucidation of parasite protein trafficking pathways from intracellular parasites to the erythrocyte cytosol and host cell membrane.
2) Determinantion of the mechanism of hemoglobin uptake and transport by intraerythrocytic parasites.
3) Characterization of parasite DNA repair pathways (e.g. base excision and mismatch repair). Continued identification of the cellular components of these trafficking pathways to gain a better understanding of transport mechanisms in malaria-infected erythrocytes.

Uitto, M.D., Ph.D., Jouni J.
Phone: (215) 503-5785
Email: Jouni.Uitto@jefferson.edu

(University of Helsinki, 1970) Professor and Chair, Department of Dermatology and Cutaneous Biology; Professor of Biochemistry and Molecular Pharmacology; Director, Jefferson Institute of Molecular Medicine.
Research Interests: Molecular biology of the cutaneous basement membranes; genetic disorders of the skin; heritable connective tissue disorders.
Funding Support: National Institutes of Health (NIAMS); Dermatology Foundation.

Van Bockstaele, Ph.D., Elisabeth J.
Phone: 215-503-1245

B.A., Sarah Lawrence College, Biology, 1985 M.S., New York University, Neurobiology, 1988 Ph.D., New York University, Neurobiology, 1991 Dr. Van Bockstaele is an active faculty member in the education of medical students and residents at TJU. She coordinates basic science research activities focused in the neurosciences and assists residents in developing research projects during their research rotations. As a mentor for numerous graduate and medical students over the past ten years, Dr. Van Bockstaele has demonstrated expertise in training postgraduate students. Her participation on NIH study sections aimed at supporting research programs for PhD, MD and MD/PhD applicants will facilitate the submission of such proposals from current neuroscience graduate students and neurosurgical residents.

Waldman, M.D., Ph.D., Scott A.
Phone: (215) 955-6086
Email: Scott.Waldman@jefferson.edu

Professor; Ph.D., Thomas Jefferson, 1980; M.D., Stanford, 1987. Molecular mechanisms of signal transduction, with emphasis on receptor-effector coupling and post-receptor signaling mechanisms; molecular mechanisms underlying tissue-specific transcriptional regulation; translation of molecular signaling mechanisms to novel diagnostic and therapeutic approaches to patients with cancer.

Wedegaertner, Ph.D., Philip B.
Phone: 215-503-3137
Email: Philip.Wedegaertner@mail.jci.tju.edu

Ph.D., University of California, San Diego, CA. 1991. G-protein signal transduction; molecular mechanisms and functions of covalent modifications and regulated subcellular localization.

Winter, Ph.D., Edward 
Phone: (215) 503-4139
Email: Edward.Winter@jefferson.edu

Ph.D., SUNY at Stony Brook, 1984. Meiotic development; chromosome structure and function; MAP kinase signaling pathways in yeast.