Course Profile

Mechanisms of Birth Defects   ( 3.00 credits )

Course Number:635
CRN Number:70546
Term:Spring 2010
Start Date End Date Time Day Building Room #
05/25/2010 05/25/2010 03:30 pm-06:30 pm Tue JAH 139
05/26/2010 06/11/2010 03:30 pm-06:30 pm Tue JAH M24
03/22/2010 05/24/2010 03:30 pm-06:30 pm Tue JAH M24
Prerequisites:  None Specified 
Exception dates & alternate classrooms:  On 4/8 class will be held in MOB 302 from 330- 430 and then in JAH M 25 from 430-630. 
Instructor:  Grunwald 

Course Description: 

Teratology is the study of birth defects and their causes and includes investigations pertaining to both structural and functional abnormalities. About 2-3% of live born infants have detectable congenital malformations at birth; the incidence often doubles by the end of the first year of life due to the discovery of abnormalities which were indiscernible at birth. These figures still do not account for the interuterine growth retardation and prenatal deaths. Like carcinogenesis, teratogenesis involves complex interactions between the genome and environment of an individual. This course will explore these interactions as they pertain to the pregnant mother and fetus, integrating information regarding causal signals of abnormal development thethe transduction of these signals into a teratogenic lesion and the genes which are likely to be determining factors in abnormal embryonic development. It will also encompass a unit on applied tetrology fron the perspective of pharmaceutical testing to determine how human teratogens are discovered. 

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