Department Chairman
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Benovic, Ph.D., Jeffrey L.
Professor and Chairman
Phone: 215-503-4607
Email: benovic@mail.jci.tju.edu
Ph.D., Duke University, 1986. Mechanisms involved in regulating G
protein-coupled receptor function and how dysregulation of these
receptors can lead to disease.
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Department Faculty
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Alnemri, Ph.D., Emad
Professor
Phone: 215-503-4632
Email: E_Alnemri@mail.jci.tju.edu
Ph.D., Temple University School of Medicine, Philadelphia, PA 1991. Molecular mechanisms of programmed cell death (apoptosis); signal transduction by death receptors in apoptosis and cancer; intracellular apoptosis regulating complexes.
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Cingolani, Ph.D., Gino
Associate Professor
Phone: 215-503-4573
Email: Gino.Cingolani@jefferson.edu
Ph.D. European Molecular Biology Laboratory, Grenoble, France 1999. My laboratory uses X-ray crystallography, combined with biophysical and biochemical techniques to probe the structure and function of large macromolecular machines.
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Fernandes-Alnemri, Teresa
Research Assistant Professor
Phone: 215-503-4631
Email: t_alnemri@mail.jci.tju.edu
Ph.D., Thomas Jefferson University, Philadelphia, PA 1994. The mechanism of caspase-1 activation during apoptosis and inflammation by cellular proteins such as 1paf (1CE protease activating factor), ASC, and several pyrin domain-containing proteins.
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Fortini, Ph.D., Mark
Associate Professor
Phone: 215-503-7322
Email: mark.fortini@jefferson.edu
Ph.D., University of California-Berkeley, 1990. Signaling mechanisms in neurogenesis and neurodegeneration; cell biology of Notch receptor trafficking and proteolysis; developmental genetics and human disease modeling in Drosophila.
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Freedman, PhD, Leonard P.
Professor, Vice Dean for Research, Jefferson Medical College
Phone: 215-955-2012
Email: leonard.freedman@jefferson.edu
Ph.D., University of Rochester, 1986. Molecular mechanisms of transcriptional regulation by nuclear hormone receptors; identification and characterization of novel therapeutic targets involved in musculoskeletal diseases
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Fujioka, Miki
Research Instructor
Email: Miki.Fujioka@jefferson.edu
Ph.D., Graduate School of Biosphere Sciences, Hiroshima University, Hiroshima, Japan 1989.
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Gamper Jr, Howard
Research Assistant Professor
Phone: 215-503-9798
Email: Howard.Gamper@jefferson.edu
Ph.D., University of California, Berkeley, CA. 1979. Nucleic acid biochemistry including pseudo-complementary bases and orthogonal base pairs; mechanism of strand exchange; sequence-specific targeting of DNA and RNA.
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Hou, Ph.D., Ya-ming
Professor
Phone: 215-503-4480
Email: Ya-Ming.Hou@jefferson.edu
Ph.D., University of California, Berkeley, CA, 1986. Structure-function and enzymatic analysis of enzyme-tRNA interactions.
Aminoacyl-tRNA synthetases; template-independent CCA polymerase; methyl
transferases; tRNA repair; tRNA-ribosome communication
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Jaynes, Ph.D., James B.
Professor
Phone: 215-503-4778
Email: jaynes@jci.tju.edu
Ph.D., University of Washington, Seattle, WA 1980. Developmental genetics and molecular biology of processes regulated by homeodomain transcription factors and higher order chromatin structure.
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Johnson, Ph.D., Erica S.
Associate Professor
Phone: (215) 503-4616
Email: Erica.Johnson@jefferson.edu
Ph.D., M.I.T., 1992. The ubiquitin-related protein Smt3/SUMO; its conjugation pathway and function in yeast.
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Kaji, Ph.D., Hideko
Professor
Phone: 215-503-6547
Email: Hideko.Kaji@jefferson.edu
Ph.D., Purdue, Molecular mechanisms/function of A) prokaryotic and eukaryotic ribosome recycling in protein synthesis B) protein modification by arginylation via arginyl tRNA protein transferase.
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Keen, Ph.D., James H.
Professor
Phone: 215-503-4624
Email: Jim.Keen@mail.jci.tju.edu
Ph.D., Cornell (Ithaca), 1976. Molecular mechanisms of membrane trafficking studied using biochemical, cell biological and live cell imaging approaches.
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Mazo, Ph.D., Alexander M.
Professor
Phone: 215-503-4785
Email: mazo@mail.jci.tju.edu
Ph.D., Institute of Molecular Biology, Moscow, Russia, 1976. Transcriptional regulation by epigenetic factors and nuclear hormone receptors.
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Merry, Ph.D., Diane E.
Associate Professor
Phone: (215) 503-4907
Email: Diane.Merry@jefferson.edu
Ph.D., University of Pennsylvania. The research in my lab centers on understanding the molecular pathways by which motor neurons become dysfunctional in response to expression of polyglutamine-expanded androgen receptor in the neurodegenerative disease spinal and bulbar muscular atrophy. In a more general sense, these studies are designed to understand how neurons respond to the accumulation of misfolded proteins. Thus, much of the research in my lab is disease-driven basic research.
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Pascal, Ph.D., John M
Assistant Professor
Phone: 215-503-4596
Email: John.Pascal@mail.jci.tju.edu
Ph.D., University of Texas, Austin, TX 2000. Structural biology of genome maintenance and chromosomal metabolism;
macromolecular x-ray crystallography; DNA replication and repair;
biochemistry and biophysics of nucleic acid enzymes
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Petruk, Svetlana
Instructor
Phone: 215-503-4784
Email: s_petruk@mail.jci.tju.edu
Ph.D.,Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia 1996
Area of research: Epigenetic regulation of gene expression in Drosophilia.
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Riobo, Ph.D., Natalia A.
Assistant Professor
Phone: 215-503-8549
Email: natalia.riobo@jefferson.edu
Ph.D., University of Buenos Aires. Signal transduction mechanisms employed by mammalian Hedgehog proteins in
stem cells, endothelium and stromal fibroblasts in the context of cardiovascular
regenerative medicine and cancer biology.
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Ronner, Ph.D., Peter
Professor
Phone: 215-503-5190
Email: Peter.Ronner@jefferson.edu
Ph.D., Swiss Federal Institute of Technology, 1978. Control of insulin and glucagon release; regulation of ATP-sensitive K-channels and voltage-dependent Ca-channels; role of cellular metabolism in signal transduction.
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Root, M.D., Ph.D., Michael
Associate Professor
Phone: 215-503-4564
Email: mroot@mail.jci.tju.edu
M.D., Harvard Medical School, Boston, MA 1997. Ph.D., Harvard University, Cambridge, MA 1997. Structure and function of glycoproteins involved in viral and cell-cell membrane fusion; design of viral entry inhibitors and immunogens for vaccine development.
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Scott, Ph.D., Charles P.
Assistant Professor
Phone: 215-503-4569
Email: cscott@mail.jci.tju.edu
Ph.D., University of Pennsylvania, Philadelphia, PA, 1997. Combinatorial drug discovery; rational drug design; chemical genomics of
host-pathogen interactions and cancer; mechanism of drug and hormone
resistance in breast cancer; mechanism of TCL1 oncogene in CLL.
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Sedkov, Yourii
Research Instructor
Phone: (215) 503-4784
Email: Yurii.Sedkov@jefferson.edu
Ph.D., Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 1989. Nuclear hormone receptors comprise a large superfamily of ligand-inducible transcription factors, which govern a wide range of complex physiological events, triggering the onset of key steps during development. Nuclear receptors are associated with a plethora of pathologies, including developmental defects, metabolic diseases and hormone-related cancers of the breast and prostate.
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Wedegaertner, Ph.D., Philip B.
Professor
Phone: 215-503-3137
Email: Philip.Wedegaertner@mail.jci.tju.edu
Ph.D., University of California, San Diego, CA. 1991. G-protein signal transduction; molecular mechanisms and functions of covalent modifications and regulated subcellular localization.
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Wickstrom, Ph.D., Eric
Professor
Phone: (215) 955-4578
Email: eric@tesla.jci.tju.edu
PhD, University of California, Berkeley, 1972. Nanotube sensing of
circulating cancer cells in blood; genetic diagnosis of cancer by mRNA
imaging; siRNA and antigenomic oligonucleotide inhibition of cancer gene
expression; nonviral gene insertion at defined sequences for treatment of
congenital diseases;covalent bonding of therapeutics to metal and plastic
medical implants for long term protection. Funded by National Cancer
Institute, Department of Energy, Department of Defense.
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Winter, Ph.D., Edward
Professor
Phone: (215) 503-4139
Email: Edward.Winter@jefferson.edu
Ph.D., SUNY at Stony Brook, 1984.
Meiotic development; chromosome structure and function; MAP kinase signaling pathways in yeast.
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Emeritus Professors:
Allen, Arthur, Ph.D.
Kalf, George, Ph.D.
Maurer, Paul, Ph.D.
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