Jeffrey Benovic, PhD

Contact Dr. Benovic

233 South Tenth Street

Philadelphia, PA 19107

(215) 503-4607
(215) 503-5393 fax

Research and Clinical Interests
Molecular and regulatory properties of G protein-coupled receptors role of receptor dysregulation in cancer and neurological disorders.

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Publications

Most recent Peer-reviewed Publications

1. β-Arrestins and G protein-coupled receptor trafficking
2. Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor
3. G-protein-coupled receptors signal victory
4. Identification and characterization of distinct c-terminal domains of the human hydroxycarboxylic acid receptor-2 that are essential for receptor export, constitutive activity, desensitization, and internalization
5. G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition
6. Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in Vivo
7. G protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression
8. Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth
9. Differential expression of arrestins is a predictor of breast cancer progression and survival
10. Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder
11. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4
12. Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but β-arrestin-independent pathways
13. Identification of the Rac-GEF P-Rex1 as an Essential Mediator of ErbB Signaling in Breast Cancer
14. Internalization of the human nicotinic acid receptor GPR109A is regulated by Gi, GRK2, and arrestin3
15. Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity
16. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function
17. Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
18. Deletion of the distal COOH-terminus of the A 2B adenosine receptor switches internalization to an arrestin- and clathrin-independent pathway and inhibits recycling
19. G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα
20. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking

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