Noreen J. Hickok, PhD

Contact Dr. Hickok

233 South 10th Street

Philadelphia, PA 19107

(215) 955-6979
fax

Research and Clinical Interests
Infection following placement of therapeutic implants is a devastating complication that results in pain, increased disability, and the need for aggressive therapeutic intervention.

Show Details

Publications

Most recent Peer-reviewed Publications

1. Reversible swelling of chitosan and quaternary ammonium modified chitosan brush layers: Effects of pH and counter anion size and functionality
2. Covalent attachment of P15 peptide to titanium surfaces enhances cell attachment, spreading, and osteogenic gene expression
3. Immobilized antibiotics to prevent orthopaedic implant infections
4. Vancomycin-modified implant surface inhibits biofilm formation and supports bone-healing in an infected osteotomy model in sheep: A proof-of-concept study
5. Antibacterial biomimetic hybrid films
6. Molecular engineering of an orthopaedic implant: From bench to bedside
7. Symmetric pH-dependent swelling and antibacterial properties of chitosan brushes
8. Antibacterial activity of bone allografts: Comparison of a new vancomycin-tethered allograft with allograft loaded with adsorbed vancomycin
9. Vancomycin bonded to bone grafts prevents bacterial colonization
10. Bacterial colonization of bone allografts: Establishment and effects of antibiotics
11. Antibiotic modification of native grafts: Improving upon nature's scaffolds
12. Topographic features retained after antibiotic modification of Ti alloy surfaces: Retention of topography with attachment of antibiotics
13. A novel short hairpin RNA (shRNA) expression system promotes Sox9-dependent gene silencing
14. Controlled release of vancomycin from thin sol-gel films on implant surfaces successfully controls osteomyelitis
15. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection
16. Antibiotics for local delivery systems cause skeletal cell toxicity in vitro
17. Vancomycin bound to Ti rods reduces periprosthetic infection: Preliminary study
18. Covalently attached vancomycin provides a nanoscale antibacterial surface
19. Vancomycin covalently bonded to titanium alloy prevents bacterial colonization
20. Covalent bonding of vancomycin to Ti6Al4V alloy pins provides long-term inhibition of Staphylococcus aureus colonization

View All Publications