Graduate Program in Biochemistry & Molecular Pharmacology
Faculty
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Emad Alnemri, PhD Professor, Biochemistry & Molecular Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular mechanisms of programmed cell death (apoptosis); Pattern recognition receptors and inflammasome activation in innate immune responses to molecular danger signals; role of mitochondria in survival, cell death and aging. |
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Andrew E. Aplin, PhD Associate Professor, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Targeting mutant BRAF and integrin signaling in melanoma. |
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Jeffrey L. Benovic, PhD Professor and Chair, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology Molecular and regulatory properties of G protein–coupled receptors; role of receptor dysregulation in cancer and neurological disorders. |
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Jonathan R. Brody, PhD Assistant Professor Director, Division of Surgical Research Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Novel therapeutic strategies for pancreatic cancer patients; primarily focused on HuR biology as it relates to the clinical management of cancer, including identifying clinically relevant HuR targets. |
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Bruno Calabretta, MD, PhD Professor, Cancer Biology Molecular Biology and Gene Regulation Molecular mechanisms of normal hematopoiesis and BCR/ABL-dependent leukemogenesis. |
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Gino Cingolani, PhD Associate Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology Molecular cell biology of Nucleocytoplasmic Transport; X-ray crystallography and biophysical analysis of viral DNA-pumping machinery; structure of multi-subunit ATP synthases. |
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Matthew Dalva, PhD Associate Professor, Neuroscience Molecular and Cellular Pharmacology The long-range goal of my research program is to understand how synapses and functional neural circuits are generated. |
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Adam P. Dicker, MD, PhD Professor and Chair, Radiation Oncology Molecular and Cellular Pharmacology Molecular pharmacology and therapeutics; testing novel anti-cancer agents both pre-clinically and clinically with ionizing radiation and current systemic therapies. |
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Masumi Eto, PhD Associate Professor, Molecular Physiology & Biophysics Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Signal transduction in controlling cytoskeletons and protein phosphatases. |
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John L. Farber, MD Professor, Pathology, Anatomy & Cell Biology Molecular and Cellular Pharmacology Biochemical mechanisms of cell injury in ischemia; biochemical toxicology of liver cell necrosis; biochemical toxicology of activated oxygen; chemical carcinogenesis. |
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Flemming Forsberg, MD Professor, Radiology Chemical and Structural Biology, Molecular & Cellular Pharmacology, Molecular Biology & Gene Regulation Contrast enhanced ultrasound imaging, in particular subharmonic imaging and subharmonic aided pressure estimation, as well as ultrasound image processing and Elastography. |
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Mark Fortini, PhD Associate Professor, Biochemistry & Molecular Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Developmental signaling pathways involved in normal cellular patterning and cancer; proteolytic mechanisms in neurogenesis and neurodegeneration; trafficking and post-translational regulation of cell-surface receptors and ligands. |
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Philippe Frank, PhD Associate Professor, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Plasma lipoproteins transport and function in human diseases. |
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Linda E. Greenbaum, MD Associate Professor, Cancer Biology Molecular Biology and Gene Regulation Mechanisms of liver regeneration and repair by hepatocytes and liver progenitor/stem cells; contribution of these processes to the development of liver fibrosis and hepatocellular carcinoma. |
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Noreen J. Hickok, PhD Associate Professor, Orthopaedic Surgery Chemical and Structural Biology, Molecular and Cellular Pharmacology Development of surfaces for combating implant-associated infection; bacterial-osteoblastic cell interactions; role of extracellular bone matrix in bone formation, bacterial adhesion, and latent infections. |
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Jan B Hoek, PhD Professor, Pathology, Anatomy & Cell Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Systems biology of intracellular signal transduction networks; deregulation of cytokine and growth factor signaling in the liver associated with chronic alcohol consumption; early signaling responses during liver regeneration; bioenergetics and mitochondrial metabolism and its role in intracellular signaling and apoptosis. |
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Michael Holinstat, PhD Assistant Professor, Medicine, Division of Hematology Chemical and Structural Biology, Molecular and Cellular Pharmacology Regulation of protease-activated receptor (PAR) function in the platelet; signal transduction and regulation of hemostasis and thrombosis in the platelet; Regulation of the small GTPase Rap1 in vascular function; regulation of platelet-mediated hemostasis and thrombosis and signal transduction by 12-Lipoxygenase; 12-Lipoxygenase as a novel approach to anti-platelet therapy; study how platelet function regulates the progression of a number of cardiovascular risks such as diabetes and acute coronary syndrome |
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Ya-ming Hou, PhD Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular & Cellular Pharmacology, Molecular Biology & Gene Regulation Genetic and biochemical studies of tRNA, including structure and function mechanism of tRNA aminoacylation, maintenance of the tRNA 3' end, maturation and processing, editing and repair, decoding on the ribosome, and development of bacterial pathogenesis in infectious diseases; targeting tRNAs as strategies against metabolic and neurodegenerative disorders. |
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Koichi Iijima, PhD Assistant Professor, Neuroscience Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Alzheimer's disease tauopathies; neurodegenerative diseases; protein misfolding; protein degradation; stress response; mitochondria; energy metabolism; neurobiology and genetics of Drosophila. |
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Kanae Iijima-Ando, PhD Research Assistant Professor, Neuroscience Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Pathobiology of tauopathies and Alzheimer's disease; Drosophila model of degenerative diseases; circadian rhythm-regulated behavior. |
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James B. Jaynes, PhD Professor, Biochemistry & Molecular Biology Molecular Biology and Gene Regulation Developmental genetics and molecular biology of gene regulation by epigenetic transcriptional memory and chromosomal architecture. |
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Hideko Kaji, PhD Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular mechanisms/function of A) prokaryotic and eukaryotic ribosome recycling in protein synthesis B) protein modification by arginylation via arginyl tRNA protein transferase. |
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Caleb B. Kallen, MD, PhD Associate Professor,Department of Obstetrics & Gynecology Molecular Biology and Gene Regulation Our lab is investigating the role of mRNA-binding proteins in obesity-related inflammatory processes with a focus on insulin sensitivity and atherosclerosis. |
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James H. Keen, PhD Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology Molecular mechanisms of membrane trafficking in normal and pathological processes using live cell imaging. |
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Karen E. Knudsen, PhD Professor, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Translational prostate cancer research, cell cycle control, hormonal control of gene transcription, chromatin remodeling. |
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Lucia R. Languino, PhD Professor, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Studies of the signaling pathways that contribute to prostate cancer progression and metastasis. |
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My G. Mahoney, PhD Associate Professor, Dermatology & Cutaneous Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Roles of desmosomal proteins in regulating epithelial cell adhesion, growth and survival; deregulation of desmosomal proteins in autoimmune, infectious, and inherited diseases associated with fragility and abnormality in diverse tissues such as the skin, hair and heart; mechanisms by which desmosomal cadherins can modulate mitogenic signaling pathways; genetically manipulated animal models to study human diseases. |
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Alexander M. Mazo, PhD Professor, Biochemistry & Molecular Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Chromatin modifications by epigenetic factors and nuclear hormone receptors. |
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Steven McMahon, PhD Professor, Cancer Biology Molecular Biology and Gene Regulation Biochemical and genetic pathways regulated by the MYC oncoprotein and the p53 tumor suppressor. |
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Diane E. Merry, PhD Associate Professor, Biochemistry & Molecular Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular pathogenesis of spinal and bulbar muscular atrophy and other polyglutamine expansion diseases; protein misfolding and aggregation in neurodegenerative disease; mouse models of neurologic disease; domain function in trafficking and degradation of the androgen receptor; gene and pharmacological therapies for neurodegenerative diseases. |
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Andrea Morrione, PhD Research Associate Professor, Urology Chemical and Structural Biology, Molecular Biology and Gene Regulation Characterization of Insulin-like Growth Factor Receptor I (IGF-IR) and IR-A (insulin receptor isoform A) function in bladder cancer initiation and progression. Role of the growth factor progranulin (proepithelin) and its receptor in bladder cancer. Characterization of the role of adaptor protein Grb10 in the regulation of IGF-IR and IR-A ubiquitination, trafficking, and signaling. |
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Marja Nevalainen, MD, PhD Associate Professor, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Stat transcription factors in prostate cancer. |
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John M. Pascal, PhD Assistant Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Structural biology of DNA replication, repair and signaling mechanisms; mechanisms of genome maintenance and chromosomal metabolism; biochemical and biophysical studies of nucleic ACID enzymes; macromolecular x-ray crystallography |
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Piera Pasinelli, PhD Associate Professor, Neuroscience Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular mechanisms of motor neuron degeneration and death in amyotrophic lateral sclerosis (ALS); role of superoxide dismutase in cell survival and death; mitochondrial dysfunction in neurodegeneration and neurodegenerative diseases; animal models of ALS; development of cell-based assays for drug screening. |
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Richard G. Pestell, MD, PhD Professor and Chair, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular mechanisms and gene therapy of breast and prostate cancer; cancer stem cell |
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Giovanni M. Pitari, MD, PhD Associate Professor, Pharmacology & Experimental Therapeutics Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Cyclic GMP signaling pathway, vasodilator-stimulated phosphoprotein (VASP), and matrix metalloproteinase 9 (MMP-9): molecular mechanisms, signaling networks and targeted therapy. |
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Andrew Alan Quong, PhD Associate Professor, Cancer Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology Proteomics and Computational biology aimed at understanding the basic mechanisms of tumorigenesis and metastasis and for the development of new molecular interventions. Development of new technologies for clinical diagnostics. Discovery of Molecular markers for early detection of breast and thyroid cancer and for prediction of response to therapy |
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Isidore Rigoutsos, PhD Professor, Pathology, Anatomy & Cell Biology Chemical and Structural Biology, Molecular Biology and Gene Regulation Pattern discovery; motif discovery; regulatory motifs; microRNAs; miRNAs; piRNAs; microRNA and piRNA targeting; non-coding RNAs; RNAi; RNA interference; retrotransposons; cell process regulation; genomics; computational genetics; computational medicine; diagnostics; therapeutics; high-throughput sequencing analysis; microbial genomics; metagenomics; high performance computing. |
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Natalia A. Riobo, PhD Assistant Professor, Biochemistry & Molecular Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Signal transduction mechanisms employed by mammalian Hedgehog proteins in cardiomyoctes, endothelium, cancer cells and stromal fibroblasts in the context of cardiovascular regenerative medicine and cancer. |
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Ulrich Rodeck, MD Professor, Dermatology & Cutaneous Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Regulation of epithelial cell fate by the epidermal growth factor receptor and associated signal transduction events; molecular mechanisms leading to adverse events of cancer therapy; adverse event reduction by developing drugs targeted to disease sites; zebrafish as an in vivo model system to investigate whole organism genotoxic stress responses. |
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Peter Ronner, PhD Professor, Biochemistry & Molecular Biology Molecular and Cellular Pharmacology Control of insulin and glucagon secretion; regulation of ATP-sensitive K channels and voltage-dependent Ca channels; role of cellular metabolism in signal transduction. |
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Michael Root, MD, PhD Associate Professor, Biochemistry & Molecular Biology Chemical and Structural Biology Structure and function of glycoproteins involved in viral and cell-cell membrane fusion; design of viral entry inhibitors and immunogens for vaccine development; antibody-antigen interactions. |
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Hallgeir Rui, MD, PhD Professor, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Signal transduction and biology of prolactin, growth hormone, and JAK-STAT pathways, with a focus on translational research on drug response prediction in human breast cancer. |
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Matthias Schnell, PhD Professor, Microbiology & Immunology Molecular Biology and Gene Regulation Development of novel vaccines and viral pathogenesis |
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Charles P. Scott, PhD Assistant Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology Combinatorial target and drug discovery; chemical genomics of host-pathogen interactions and cancer. |
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Ross Summer, MD Associate Professor, Medicine, Pulmonary & Critical Care Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Dr Summer's laboratory focuses on lung metabolism and understanding how local and systemic metabolic derangements contribute to the onset and progression of lung diseases. |
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Jianxin Sun, PhD Associate Professor, Medicine, Center for Translational Research Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Dissecting the molecular mechanisms regulating Endothelial Nitric Oxide Synthase (eNOS) expression and vascular inflammation in the vascular wall. |
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Davide Trotti, PhD Associate Professor, Neuroscience Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular pathogenesis of amyotrophic lateral sclerosis (ALS); glutamate transporter regulation and excitotoxic mechanisms in neurodegenerative diseases; biophysics of mitochondria conductances in ALS. |
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Jouni Uitto, MD, PhD Professor and Chair, Dermatology & Cutaneous Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular genetics of the cutaneous basement membrane zone; regulation of collagen and elastin gene expression and the molecular basis of heritable and acquired connective tissue diseases. |
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Scott A. Waldman, MD, PhD Professor and Chair, Pharmacology & Experimental Therapeutics Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Molecular mechanisms of signal transduction, with emphasis on receptor-effector coupling and post-receptor signaling mechanisms; molecular mechanisms underlying tissue-specific transcriptional regulation; translation of molecular signaling mechanisms to novel diagnostic and therapeutic approaches to patients with cancer. |
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Philip B. Wedegaertner PhD Professor, Biochemistry & Molecular Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Heterotrimeric G-protein, Rho GTPase, and Rho guanine-nucleotide exchange factor (RhoGEF) signaling and cell biology; mechanisms and functions of regulated subcellular localization and trafficking. |
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Eric Wickstrom, PhD Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology Sensing, imaging, regulation, and control of oncogene expression in cells and animal models with nucleic acid derivatives. |
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Edward Winter, PhD Professor, Biochemistry & Molecular Biology Chemical and Structural Biology, Molecular and Cellular Pharmacology Analysis of meiotic development using molecular genetics in yeast; signal transduction and protein kinases; transcriptional regulation. |
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Teresa Zimmers, PhD Associate Professor, Cancer Biology Molecular and Cellular Pharmacology, Molecular Biology and Gene Regulation Cachexia; regeneration; molecular biology; STAT3; IL-6; myostatin; TGF-beta superfamily; liver regeneration; muscle atrophy; microarray; C2C12 myofibers; primary cultures; translational research; cancer; oncology; burn injury; muscle wasting; ACVR2B; cytokines; inflammation |
