1025 Walnut Street
Suite 312
Philadelphia, PA 19107
(215) 503-5157
(215) 503-5731 fax
Suite 312
Philadelphia, PA 19107
(215) 503-5157
(215) 503-5731 fax
Most Recent Peer-reviewed Publications
- N-cadherin haploinsufficiency affects cardiac gap junctions and arrhythmic susceptibility
- N-cadherin is required for neural crest remodeling of the cardiac outflow tract
- Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis
- N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis
- Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure
- N-cadherin is not essential for limb mesenchymal chondrogenesis
- Cadherin-mediated adhesion is essential for myofibril continuity across the plasma membrane but not for assembly of the contractile apparatus
- Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart
- Differential adhesion leads to segregation and exclusion of N-cadherin-deficient cells in chimeric embryos
- Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin