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Cardiovascular Disease Prevention Center

Sound Waves May Help Stop Arteries from Re-Clogging
(Published 2-1-2002) Cardiologists at Jefferson Medical College are participating in an international study to see if ultrasound, long known for its diagnostic uses, can actually help prevent coronary arteries leading to the heart from clogging up again after they’ve already been cleaned out once.

Mutations Identified in Gene Causing Blindness, Early Heart Attacks in Rare Inherited Disorder
(Published 7-1-2001) Molecular geneticists at Jefferson Medical College have for the first time characterized gene mutations in families affected by a rare, inherited, connective tissue disorder that can lead to blindness and early heart attacks.

A Randomized, Double-Blind, Parallel-Group Evaluation of Cerivastatin 0.8 mg Compared to Cerivastatin 0.4 mg and Placebo/Pravastatin 20 mg Once Daily in Patients with Hypercholesterolemia
Protocol: D97-008
Sponsor: Bayer Corporation
Dates: 11/97 - 11/99
Principal Investigator: David Capuzzi, MD

Effects of Walnuts Consumed in Conjunction with the National Cholesterol Educational Panel Step I Diet on Serum Lipids and Coagulation Parameters
Sponsor: California Walnut Commission
Dates: 3/98 - 12/99
Principal Investigator: David Capuzzi, MD

A Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Ranging (0.25 to 10 mg) Clinical Evaluation of Oral G1262570X as a Monotherapy in Subjects with Type 2 Diabetes Mellitus
Sponsor: Glaxo Wellcome, Inc.
Dates: 5/98 - 4/00
Principal Investigator: David Capuzzi, MD

A Randomized Trial Comparing the Efficacy and Safety of a Combination of HMG Co-A Reductase Inhibitor and Spread Containing Plant Stanol Esters Versus HMG Co-A Reductase Inhibitor and Placebo Spread to Help Reduce LDL and Total-Cholesterol Levels
Sponsor: McNeil Consumer Products Co.
Dates: 5/98 - 5/00
Principal Investigator: David Capuzzi, MD

A Multi Six-Week Randomized Open-Label Parallel-Arm Study Comparing the Efficacy of Once Daily Atorvastatin to Simvastatin in Hypercholesterolemic Patients (the challenge study)
Protocol: 981-400-320
Sponsor: Parke Davis
Dates: 10/98 - 10/99
Principal Investigator: David Capuzzi, MD

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