Thomas Jefferson University - Francesco Del Galdo
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Francesco Del Galdo
Dermatology and Cutaneous Biology
Thomas Jefferson University
Jefferson Medical College
Assistant Professor
Department of Dermatology & Cutaneous Biology
Assistant Professor
Department of Cancer Biology
(Secondary Appointment)
Associate Director
Jefferson Scleroderma Center
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Mailing Address
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233 South 10th Street,
Suite 419 BLSB
Philadelphia, Pennsylvania 19107
United States
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Qualifications
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M.D. Second University of Naples, Italy, 1999.
Ph.D. Immunology, Second University of Naples, Italy, 2007.
Post-doctoral fellowship, Rheumatology, 2005-2007.
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Expertise and Research Interests
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Primary interests:
1) Early events in the pathogenesis of Systemic Sclerosis (Scleroderma)
2) Characterization of biomarkers for early diagnosis and assessment of disease activity in fibrotic conditions
Dr. Del Galdo's studies focus on the events that bridge between the aberrant activation of the immune system and the profibrotic phenotype of tissue fibroblasts in Systemic Sclerosis. His studies have broadened the understanding of the similarities between Systemic Sclerosis pathogenesis and chronic allograft rejection through studying the role of the peculiar expression of Allograft Inflammatory Factor-1 in Scleroderma. His research has recently led to the identification of the downregulation of caveolin-1 as the key molecular switch in the activation of tissue fibroblasts in Scleroderma. These studies have paved the way for a new animal model of SSc and contributed to the identification of caveolin-1 bioavailability as a potential therapeutic target in fibrotic conditions.
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Keywords
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Scleroderma, vascular rejection, autoimmune systemic diseases, cell adhesion
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Publications
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- Del Galdo F, Sotgia F, de Almeida C, Jasmin JF, Musick M, Lisanti MP, Jimenez SA (2008) Decreased expression of caveolin-1 in systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. Arthritis Rheum 58:2854-2865.
- Del Galdo F, Lisanti MP, Jimenez SA (2008) Caveolin-1, TGF-² receptor internalization, and the pathogenesis of systemic sclerosis. Current Opinion in Rheumatology (In Press).
- Del Galdo F, Jimenez SA (2007) T Cells Expressing Allograft Inflammatory Factor 1 Display Increased Chemotaxis and Induce a Profibrotic Phenotype in Normal Fibroblasts In Vitro. Arthritis Rheum 56:3478-3488.
- Del Galdo F, Maul, GG, Jimenez SA, Artlett CM (2006) Expression of allograft inflammatory factor-1 in tissues from patients with systemic sclerosis and in vitro differential expression of its isoforms in response to transforming growth factor-². Arthritis Rheum 54:2616-2625.
- Del Galdo F, Artlett CM, Jimenez SA (2006) Role of allograft inflammatory factor 1 in systemic sclerosis. Curr Opin Rheum 18:588-593.
- Del Galdo F, Artlett CM (2006) T cells and B cells in the pathogenesis of systemic sclerosis: recent insights and therapeutic opportunities. Curr Rheumatol Rep 8:123-30.
- De Palma R, Del Galdo F, Lupoli S, Altucci P, Abbate G, Valentini G (2006) Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin. Clin Exp Immunol 144:169-76.
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Individual Expertise profile of
Francesco Del Galdo, Copyright © Francesco Del Galdo.
Last Updated
by Admin
: Monday, November 24, 2008 11:49:24 AM
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