Thomas Jefferson University - Sonsoles Piera-Velazquez
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Sonsoles Piera-Velazquez
Dermatology and Cutaneous Biology
Thomas Jefferson University
Jefferson Medical College
Assistant Professor
Department of Dermatology & Cutaneous Biology
Assistant Professor
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Mailing Address
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233 South 10th Street,
Suite 422 BLSB
Philadelphia, Pennsylvania 19107
United States
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Qualifications
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Ph.D. Biochemistry. 1996 University of Alicante (Spain).
Postdoctoral Fellowship. Division of Rheumatology, Thomas Jefferson University 1999-2001.
Arthritis Foundation Fellowship. Division of Rheumatology, Thomas Jefferson University. 2001-2004.
Assistant Professor. Department of Dermatology and Cutaneous Biology, Thomas Jefferson University.
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Expertise and Research Interests
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Study of the molecular events involved in the development of articular cartilage damage in human osteoarthritis with special emphasis on alterations in chondrocyte gene expression induced by cytokines and other inflammatory mediators.
Study of the mechanisms of chondrocyte phenotype stability and of its loss during de-differentiation focusing on the role of telomerase expression, NOX4 and oxygen radicals and activation of the Wnt pathway.
Recent studies on the alterations of expression of extracellular matrix genes in the novel fibrotic disease, Nephrogenic Systemic Fibrosis, and on the role of exposure to Gadolinium (Gd) containing magnetic resonance contrast agents in its pathogenesis.
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Keywords
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Osteoarthritis, cartilage, chondrocyte phenotype and regulation of gene expression, telomerase, SOX9 promoter, Nephrogenic Systemic Fibrosis.
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Publications
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- Piera-Velázquez S, Hawkins DF, Whitecavage MK, Colter DC, Jimenez SA, and Stokes DA (2007) Regulation of the human SOX9 promoter by Sp1 and CREB, Exp Cell Res 313(6):1069-1079.
- Piera-Velázquez S, Sandorfi N, Jimenez SA. (2007) Nephrogenic Systemic Fibrosis/Nephrogenic Fibrosing Dermopathy: Clinical Aspects. Skin Med 6:24-27.
- Jimenez SA and Piera-Velázquez S. (2007) Gene expression profiling of human articular chondrocytes and osteoarthritis. In: Osteoarthritis and Inflammation. Buckwalter JA et al, Editors. IOS Press, Amsterdam, pp. 143-159.
- Mendoza FA, Artlett CM, Sandorfi N, Latinis K, Piera-Velázquez S, Jimenez SA. (2006) Description of 12 cases of Nephrogenic Fibrosing Dermopathy and review of the literature. Semin Arthritis Rheum 35:238-249.
- Colter DC, Piera-Velázquez S, Hawkins DF, Whitecavage MK, Jimenez SA, Stokes DG. (2005) Regulation of the human Sox9 promoter by the CCAAT-binding factor. Matrix Biology 24:185-197.
- Coimbra IB, Jimenez SA, Hawkins DF, Piera-Velázquez S, Stokes DG. (2004) Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes. Osteoarthritis Cart 12:336-345.
- Stokes DG, Liu G, Coimbra IB, Piera-Velázquez S, Crowl RM, Zhang P, Jimenez SA. (2002) Assessment of the gene expression profile of differentiated and de-differentiated human chondrocytes by microarray analysis. Arthritis Rheum 46(2): 404-419.
- Piera-Velázquez S, Jimenez SA, Stokes DG. (2002) Increased Life-span of Human Osteoarthritic Chondrocytes by Exogenous Expression of Telomerase. Arthritis Rheum 46(3): 683-693.
- Stokes DG, Liu G, Dharmavaram R, Hawkins D, Piera-Velázquez S, Jimenez SA. (2001) Regulation of Type II Collagen Gene Expression During Human Chondrocyte De-differentiation and Recovery of Chondrocyte-Specific Phenotype in Culture Involves Sry-type High-mobility-group Box (SOX) Transcription Factors. Biochemical J 360: 461-470.
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Individual Expertise profile of
Sonsoles Piera-Velazquez, Copyright © Sonsoles Piera-Velazquez.
Last Updated
by Admin
: Monday, November 24, 2008 11:50:06 AM
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